光动力疗法联合CO_(2)激光治疗尖锐湿疣患者的疗效及对Ang-2、HBD-2、Bcl-2和IL-8水平的影响  

Efficacy of photodynamic therapy combined with CO_(2) laser in the treatment of condyloma acuminatum patients and its influence on levels of angiopoietin-2,human beta-defensin-2,B-cell lymphoma-2 and interleukin-8

作　　者：赵军 姚盛 陶晓瑜 ZHAO Jun;YAO Sheng;TAO Xiaoyu(Department of Dermatology and Venereology,Changshu Hospital Affiliated to Soochow University(Changshu No.1 People's Hospital),Suzhou 215500,Jiangsu,China)

机构地区：[1]苏州大学附属常熟医院(常熟市第一人民医院)皮肤性病科,江苏苏州215500

出　　处：《中国性科学》2024年第3期149-152,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨光动力疗法联合CO_(2)激光治疗尖锐湿疣(CA)的疗效及对促血管生成素-2(Ang-2)、人β-防御素2(HBD-2)、B淋巴细胞瘤-2基因(Bcl-2)、白介素-8(IL-8)水平的影响。方法选取2021年1月至2022年10月苏州大学附属常熟医院收治的68例CA患者作为研究对象。采用随机数字表法将其分为激光组和光动力组,每组34例。激光组采用CO_(2)激光治疗,光动力组在激光组基础上联合使用5-氨基酮戊酸光动力疗法(ALA-PDT)治疗,比较两组临床疗效、皮损组织中人乳头瘤病毒(HPV)转阴率、治疗前后外周血水平变化,统计两组治疗期间不良反应发生情况。结果治疗后6个月,光动力组总复发率显著低于激光组,光动力组治疗总有效率显著高于激光组,差异具有统计学意义(P<0.05)。治疗后1、2、3、6个月,两组皮损组织HPV转阴率逐渐升高,且光动力组HPV转阴率显著高于激光组,差异具有统计学意义(P<0.05)。治疗后,两组Ang-2、IL-8、Bcl-2水平均显著降低(P<0.05),HBD-2显著升高(P<0.05),且光动力组治疗后上述指标与激光组比较,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论ALA-PDT联合CO_(2)激光治疗CA患者的疗效显著,可促进HPV转阴,改善患者免疫相关指标,安全性好。Objective To explore the efficacy of photodynamic therapy combined with CO_(2) laser in the treatment of condyloma acuminatum(CA)and its influence on the levels of angiopoietin-2(Ang-2),human beta-defensin-2(HBD-2),B-cell lymphoma-2(Bcl-2)and interleukin-8(IL-8).Methods A total of 68 patients with CA admitted to in Changshu Hospital Affiliated to Soochow University from January 2021 to October 2022 were selected as the study subjects,and were divided into laser group and photodynamic group by the random number table method,with 34 cases in each group.The laser group was treated with CO_(2)laser,and the photodynamic group was given 5-aminolevulinic acid photodynamic therapy(ALA-PDT)on the basis of the laser group.The clinical efficacy,human papilloma virus(HPV)negative conversion rate in skin lesion tissue,and changes in peripheral blood indicators before and after treatment were compared between both groups,and the occurrence of adverse reactions during treatment in the two groups were analyzed.Results The total recurrence rate in photodynamic group at 6 months after treatment was significantly lower than that in laser group,while the total effective rate of treatment was significantly higher than that in laser group,with statistically significant differences(P<0.05).At 1,2,3 and 6 months after treatment,the negative conversion rate of HPV in skin lesion tissue was gradually increased in both groups,and the HPV negative conversion rate in photodynamic group was significantly higher than that in laser group,with statistically significant difference(P<0.05).The levels of Ang-2,IL-8 and Bcl-2 in both groups were significantly decreased after treatment(P<0.05),while the HBD-2 was significantly increased(P<0.05),and the above indicators in photodynamic group were statistically different from those in laser group after treatment,with statistically significant difference(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between groups(P>0.05).Conclusions ALA-PDT combine

关 键 词：尖锐湿疣 5-氨基酮戊酸光动力疗法 CO_(2)激光治疗 临床疗效 

分 类 号：R759[医药卫生—皮肤病学与性病学]