洋甘菊抗哮喘活性部位的提取工艺研究  

Study on extraction technology of anti-asthma active part of Matricarla chamomilla L.

作　　者：刘飞[1] 热依木古丽·阿布都拉[2] 信学雷[2] 李茜[1,3] LIU Fei;Rahima·Abdua;XIN Xuelei;LI Qian(Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University,Urumqi 830000,China;Key Laboratory of Plant Resources Chemistry in Arid Areas,Chinese Academy of Sciences/Utilization of Unique Medicinal Resources in Xinjiang The Provinces and Ministries Jointly Build The Cultivation Base of State Key Laboratories/Utilization of Unique Medicinal Resources in Xinjiang The Provinces and Ministries Jointly Build The Cultivation Base of State Key Laboratories,Urumqi 830011,China;Xinjiang Key Laboratory of Traditional Chinese Medicine Processing,Urumqi 830000,China)

机构地区：[1]新疆医科大学附属中医医院,乌鲁木齐830000 [2]中国科学院干旱区植物资源化学重点实验室/新疆特有药用资源利用省部共建国家重点实验室培育基地/中国科学院新疆理化技术研究所,乌鲁木齐830011 [3]新疆中药炮制研究重点实验室,乌鲁木齐830000

出　　处：《中华中医药杂志》2024年第3期1528-1534,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：新疆维吾尔自治区自然科学基金(No.2021D01E32);乌鲁木齐市科学技术局优秀青年科技人才培养项目。

摘　　要：目的:运用正交试验优化洋甘菊抗哮喘活性部位的提取工艺。方法:以洋甘菊特征成分咖啡酰基奎宁酸类(3,4-二-O-咖啡酰基奎宁酸和4,5-二-O-咖啡酰基奎宁酸)化合物的含量、提取率以及提取物抗哮喘体外筛选作为考察指标,对洋甘菊抗哮喘活性成分的提取工艺进行评价。结果:确定最优提取条件为:70%乙醇作为提取溶剂,料液比为1∶30,回流提取2次,每次提取时间2 h。结论:运用正交试验确定洋甘菊抗哮喘活性成分的最优提取工艺。Objective:To optimize the extraction process of anti-asthma active parts of chamomile by using single factor orthogonal test.Methods:The single factor orthogonal design was used to evaluate the extraction technology of anti-asthma active components of chamomile,taking the content,extraction rate and in vitro screening of anti-asthma extracts of the characteristic components of chamomile,namely caffeoyl quinic acid(3,4-di-O-caffeoyl quinic acid and 4,5-di-O-caffeoyl quinic acid)as the inspection indexes.Results:The optimal extraction conditions were determined as follows:70%ethanol was used as extraction solvent,the ratio of solid to liquid was 1:30,reflux extraction was carried out twice,and each extraction time was 2 h.Conclusion:The single factor orthogonal experiment is used to determine the optimal extraction process of anti-asthma active components of chamomile.

关 键 词：洋甘菊 抗哮喘 正交试验 提取工艺 

分 类 号：R284.2[医药卫生—中药学]