盐霉素在白色链霉菌中的生物合成及代谢调控研究进展  

Research progress on biosynthesis and metabolic regulation of salinomycin in Streptomyces albus

作　　者：郭松松 孙羽 杨怡萱 余怡铖 朱振洪[1] GUO Songsong;SUN Yu;YANG Yixuan;YU Yicheng;ZHU Zhenhong(School of Life Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China)

机构地区：[1]浙江中医药大学生命科学学院,浙江杭州310053

出　　处：《微生物学通报》2024年第3期732-742,共11页Microbiology China

摘　　要：盐霉素(salinomycin)作为一种被广泛应用于畜牧业领域的重要抗生素,是具有抗肿瘤干细胞效果的一种潜在药物,其生物合成和代谢调控机制日益受到人们的关注。本文综述了白色链霉菌(Streptomyces albus)中盐霉素的生物合成机制及其次级代谢调控研究的新进展,旨在通过对盐霉素生物合成基因簇关键蛋白、聚酮骨架链合成关键酶和调控因子的分析,提出通过次级代谢调控技术提高盐霉素产量的若干策略,为进一步开发盐霉素高产工业菌株提供参考。Salinomycin,an important antibiotic widely used in animal husbandry,is a potential drug with anti-tumor stem cell effect.Its biosynthesis and metabolic regulation mechanism have received increasing attention.In this paper,we reviewed the biosynthesis mechanism of salinomycin in Streptomyces albus and the recent progress in the study of its secondary metabolism regulation,aiming to propose some strategies to improve salinomycin production through secondary metabolism regulation technology by analyzing the key proteins of salinomycin biosynthesis gene cluster,key enzymes and regulatory factors of polyketone skeleton chain synthesis.It provides reference for further development of high-yield salinomycin industrial strains.

关 键 词：盐霉素 白色链霉菌 生物合成 代谢调控 

分 类 号：Q935[生物学—微生物学]