门诊血液透析患者丙型肝炎病毒抗体假阳性情况调查与分析  

The investigation of false positive reactions about hepatitis C virus antibody detection in maintenance hemodialysis outpatients

作　　者：钟先阳 李静 张琼鹰 陈建芸 李文丹 ZHONG Xianyang;LI Jing;ZHANG Qiongying;CHEN Jianyun;LI Wendan(Department of Nephrology,General Hospital of Southern Theater Command of PLA,Guangzhou 510010,Guangdong,China;Department of Laboratory,General Hospital of Southern Theater Command of PLA,Guangzhou 510010,Guangdong,China;Department of Blood Transfusion Medicine,General Hospital of Southern Theater Command of PLA,Guangzhou 510010,Guangdong,China)

机构地区：[1]中国人民解放军南部战区总医院肾脏病科,广东广州510010 [2]中国人民解放军南部战区总医院检验科,广东广州510010 [3]中国人民解放军南部战区总医院输血医学科,广东广州510010

出　　处：《暨南大学学报（自然科学与医学版）》2024年第1期38-42,50,共6页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的:调查门诊血液透析患者丙型肝炎病毒抗体假阳性的发生率和发生原因,以便正确处理抗体检测报告和医患沟通困扰。方法:对中国人民解放军南部战区总医院2019年12月至2022年12月279名门诊血液透析患者的丙型肝炎病毒抗体和丙型肝炎病毒RNA检测结果进行整群抽样、横断面调查和回顾性研究。结果:调查发现共有81人丙型肝炎病毒抗体假阳性,占29.03%;其中S/CO值介于1.0~5.0的占98.77%,介于5.0~10.0的占比为1.23%。全部病例经HCV-RNA复核3次,均为阴性。检验科与输血医学科采取不同的检测方法与报告程序,结果有显著性差异(P<0.01)。结论:丙型肝炎病毒抗体S/CO值处于灰区范围时多为假阳性,且与抗体检测策略和报告程序有关。Objective:To investigate the incidence and cause of false positive reaction about hepatitis C virus antibody detection in maintenance hemodialysis outpatients,in order to correctly deal with the antibody test reports and the doctor-patient communication problems.Methods:The hepatitis C virus antibody and RNA in 279 maintenance hemodialysis outpatients of General Hospital of Southern Theater Command of PLA were analyzed by cluster sampling,cross-sectional investigation and retrospective study from December 2019 to December 2022.Results:It was found that 81 patients were false positive for hepatitis C virus antibody,which accounted to 29.03%;S/CO values between 1.0 and 5.0 was 98.77%,and between 5.0 and 10.0 was 1.23%.All cases were reviewed by HCV-RNA three times,and were negative.Different detection methods and reporting procedures were chosen at the department of laboratory and the department of blood transfusion medicine,and the results were significantly different(P<0.01).Conclusion:The S/CO values of false positive reactions about hepatitis C virus antibody detection are mostly in the gray zone range and are related to the detection strategy and reporting procedure.

关 键 词：血液透析 门诊患者 丙型肝炎病毒抗体 假阳性反应 

分 类 号：R692.5[医药卫生—泌尿科学]