Are treatment options used for adult-onset type 2 diabetes mellitus(equally)available and effective for children and adolescents?  

作　　者：Nevena Krnic Vibor Sesa Anna Mrzljak Maja Cigrovski Berkovic 

机构地区：[1]Clinics for Pediatrics,University Hospital Center Zagreb,Zagreb 10000,Croatia [2]Department of Gastroenterology and Hepatology,University Hospital Centre Zagreb,Zagreb 10000,Croatia [3]University of Zagreb School of Medicine,Zagreb 10000,Croatia [4]Department for Sport and Exercise Medicine,University of Zagreb Faculty of Kinesiology,Zagreb 10000,Croatia

出　　处：《World Journal of Diabetes》2024年第4期623-628,共6页世界糖尿病杂志（英文版）（电子版）

摘　　要：Youth-onset type 2 diabetes mellitus(T2DM),influenced by an increase in obesity,is a rising problem worldwide.Pathophysiological mechanisms of this early-onset T2DM include both peripheral and hepatic insulin resistance,along with increa-sed hepatic fasting glucose production accompanied by inadequate first and second-phase insulin secretion.Moreover,the incretin effect is reduced.The initial presentation of type 2 diabetes can be dramatic and symptoms may overlap with those of type 1 diabetes mellitus.Therefore,immediate therapy should address hyperglycemia and associated metabolic derangements irrespective of ultimate diabetes type,while further therapy adjustments are prone to patients’pheno-type.New agents with proven glycemic and beyond glycemia benefits,such as Glucagon-like polypeptide 1 receptor agonists and Sodium-glucose cotransporter-2 inhibitors,used in the adult population of T2DM patients,might become increasingly important in the treatment armamentarium.Moreover,metabolic surgery is an option for markedly obese(body mass index>35 kg/m^(2))children and adolescents suffering from T2DM who have uncontrolled glycemia and/or serious comorbidities when lifestyle and pharmacologic interventions fail.In this mini-review,we will discuss the potential of treatment options considering new data available from randomized control trials,including individuals with adult-onset type diabetes mellitus.

关 键 词：Youth-onset type 2 diabetes mellitus Treatment COMPLICATIONS Glucose lowering agents Extra-glycemic benefit 

分 类 号：R725.8[医药卫生—儿科]