Associations between remnant cholesterol levels and mortality in patients with diabetes  

作　　者：Deng Pan Lin Xu Li-Xiao Zhang Da-Zhuo Shi Ming Guo 

机构地区：[1]Department of Cardiovascular,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China [2]Graduate School,Beijing University of Chinese Medicine,Beijing 100020,China [3]National Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China [4]Gynecological Department of Traditional Chinese Medicine,China-Japan Friendship Hospital,Beijing 100020,China

出　　处：《World Journal of Diabetes》2024年第4期712-723,共12页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Project of National Natural Science Foundation of China,No.82274345 and No.82104907;Fundamental Research Funds for the Central public welfare research institutes Grant,No.ZZ13-YQ-016 and No.ZZ13-YQ-016-C1.

摘　　要：BACKGROUND Dyslipidemia is frequently present in patients with diabetes.The associations of remnant cholesterol and mortality remains unclear in patients with diabetes.AIM To explore the associations of remnant cholesterol with all-cause and cardiovas-cular mortality in patients with diabetes.METHODS This prospective cohort study included 4740 patients with diabetes who par-ticipated in the National Health and Nutrition Examination Survey from 1999 through 2018.Remnant cholesterol was used as the exposure variable,and all-cause and cardiovascular mortality were considered outcome events.Outcome data were obtained from the National Death Index,and all participants were followed from the interview date until death or December 31,2019.Multivariate proportional Cox regression models were used to explore the associations between exposure and outcomes,in which remnant cholesterol was modeled as both a categorical and a continuous variable.Restricted cubic splines(RCSs)were calculated to assess the nonlinearity of associations.Subgroup(stratified by sex,age,body mass index,and duration of diabetes)and a series of sensitivity analyses were performed to evaluate the robustness of the associations.RESULTS During a median follow-up duration of 83 months,1370 all-cause deaths and 389 cardiovascular deaths were documented.Patients with remnant cholesterol levels in the third quartile had a reduced risk of all-cause mortality[hazard ratio(HR)95%confidence interval(CI):0.66(0.52-0.85)];however,when remnant cholesterol was modeled as a continuous variable,it was associated with increased risks of all-cause[HR(95%CI):1.12(1.02-1.21)per SD]and cardiovascular[HR(95%CI):1.16(1.01-1.32),per SD]mortality.The RCS demonstrated nonlinear associations of remnant cholesterol with all-cause and cardiovascular mortality.Subgroup and sensitivity analyses did not reveal significant differences from the above results.CONCLUSION In patients with diabetes,higher remnant cholesterol was associated with increased risks of all-cause and cardiovascul

关 键 词：DIABETES Remnant cholesterol MORTALITY CARDIOVASCULAR National Health and Nutrition Examination Survey 

分 类 号：R587.1[医药卫生—内分泌]