Metabolic syndrome’s new therapy:Supplement the gut microbiome  

作　　者：Yong-Wei Xu Jun Tian Yan Song Ba-Cui Zhang Jing Wang 

机构地区：[1]Department of Gastroenterology,Songjiang Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 201600,China

出　　处：《World Journal of Diabetes》2024年第4期793-796,共4页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Songjiang District Tackling Key Science and Technology Research Projects,No.20sjkjgg32;the Excellent Young Talents Training Program of Songjiang Hospital Affiliated with Shanghai Jiao Tong University School of Medicine,No.QNRC-004;Science and Technology Project of Songjiang District,No.22SJKJGG81。

摘　　要：This letter to the editor discusses the publication on gut microbiome supple-mentation as therapy for metabolic syndrome.Gut microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inflammation,insulin resistance,cardiovascular diseases,type 2 diabetes mellitus,and obesity.Previous research has found that increasing the abundance of beneficial microbiota in the gut modulates metabolic syndrome by reducing chronic inflammation and insulin resistance.Prebiotics,probiotics,synbiotics,and postbiotics are often used as supplements to increase the number of beneficial microbes and thus the produc-tion of short-chain fatty acids,which have positive effects on the gut microbiome and metabolic syndrome.In this review article,the author summarizes the available supplements to increase the abundance of beneficial gut microbiota and reduce the abundance of harmful microbiota in patients with metabolic disorders.Our group is also researching the role of the gut microbiota in chronic liver disease.This article will be of great help to our research.At the end of the letter,the mechanism of the gut microbiota in chronic liver disease is discussed.

关 键 词：Gut microbiome Metabolic syndrome Diabetes mellitus Short-chain fatty acids Chronic liver disease 

分 类 号：R587.1[医药卫生—内分泌]