配体调控Cp_(2)TiCl_(2)催化合成单、双取代苯并咪唑衍生物的研究  

The Study on Ligand-regulated Cp_(2)TiCl_(2) Catalytic Synthesis of Single,Double-substituted Benzimidazole Derivatives

作　　者：王芸芸 陆旭 李晓月 王涛 WANG Yun-yun;LU Xu;LI Xiao-yue;WANG Tao(Ningxia Key Laboratory of Green Catalytic Materials and Technology,School of Chemistry and Chemical Engineering,Ningxia Normal University,Guyuan 756000,China)

机构地区：[1]宁夏师范学院化学化工学院宁夏回族自治区绿色催化材料与技术重点实验室,宁夏固原756000

出　　处：《分子催化（中英文）》2024年第1期51-62,I0003,共13页Journal of Molecular Catalysis(China)

基　　金：宁夏回族自治区固原市科技计划项目(No.2020GYKYF004);宁夏自然科学基金项目(No.2022AAC03322);宁夏师范学院宁夏高校一流学科建设项目(化学);宁夏高等学校一流学科建设教育学学科(No.NXYLXK2021B10);宁夏师范学院六盘山资源工程技术研究中心和无机化学重点学科(宁师院[2017]83号)(No.HGZD21-09)。

摘　　要：以邻苯二胺和芳香醛为反应起始物,在50℃,乙醇为溶剂,0.02 mmol L-苯丙氨酸为催化剂条件下,催化合成产物为单取代苯并咪唑类化合物,产率可达到70%;而在50℃,以乙醇为溶剂,0.04 mmol L-苯丙氨酸为Brønsted acid配体,0.02 mmol Cp_(2)TiCl_(2)为Lewis acid的条件下,则催化生成1,2-二取代苯并咪唑类化合物,产率可达到97%.底物普适性较好,且后处理简单.同时利用NMR分析对机理进行了初步的研究.In this paper,using o-phenylenediamine and aromatic aldehydes as the starting material,under the condition of 50℃,ethanol as solvent and 0.02 mmol L-phenylalanine as catalyst,the catalytic synthesis products were monosubstituted benzimidazoles,and the yield could reach 70%.However,under the conditions of 50℃,ethanol as solvent,0.04 mmol L-phenylalanine as Brønsted acid ligand,0.02 mmol Cp_(2)TiCl_(2) as Lewis acid,the catalytic synthesis products were 1,2-disubstituted benimidazoles,and the yield reached 97%.The catalytic system presents the advantages of good universality and simple post-processing.At the same time,NMR analysis was used to investigate the mechanism.

关 键 词：二氯二茂钛 配体调控 苯并咪唑类化合物 

分 类 号：O643.32[理学—物理化学]