防晒剂原料甲氧基肉桂酸乙基己酯在三种动物替代实验中的研究  

Study on Ethylhexyl Methoxycinnamate as Sunscreen Raw Materials in Three Animal Substitution Experiments

作　　者：陈琪[1] 许姿敏[1] 霍淑霞 乔叶军 翁森 阮浩澜[1] 颜林 CHEN Qi;XU Zi-min;HUO Shu-xia;QIAO Ye-jun;WENG Sen;RUAN Hao-lan;YAN Lin(NMP Key Laboratory of Cosmetics Safety Risk Assesment,Guangdong Institute for Drug Control,Guangdong Guangzhou 510663,China)

机构地区：[1]国家药品监督管理局化妆品风险评估重点实验室,广东省药品检验所,广东广州510663

出　　处：《广州化工》2023年第22期23-25,共3页GuangZhou Chemical Industry

基　　金：广东省药品监督管理局2022年科技创新项目(No:2022TDZ08)。

摘　　要：选用化妆品防晒剂原料甲氧基肉桂酸乙基己酯,分别进行体外兔角膜上皮细胞短时暴露实验,体外3T3中性红摄取光毒性试验与皮肤变态反应:局部淋巴结试验(DA法,LLNA:DA)等动物替代实验。防晒剂原料在三个实验中结果均为阴性。动物替代实验相对于传统动物实验更高效,数据更客观并符合动物伦理要求,加快替代实验的研究、验证和认可工作,将有助于加速我国的化妆品检验标准与国际接轨。Ethylhexyl methoxycinnamate,the raw material of cosmetic sunscreen,was used to conduct the short-term exposure experiment of rabbit corneal epithelial cells in vitro,the in vitro 3T3 neutral red uptake phototoxicity test and the skin allergy was local lymph node test(DA method,LLNA:DA)respectively.Results were negative in the three animal substitution experiments for Ethylhexyl methoxycinnamate.Compared with traditional animal experiments,animal substitution experiments were more efficient,and the data were more objective and met the requirements of animal ethics.Accelerating the research,verification and approval of substitution experiments would help accelerate the cosmetics inspection standards of China to be in line with international standards.

关 键 词：甲氧基肉桂酸乙基己酯 化妆品 替代方法 动物实验 

分 类 号：R991[医药卫生—毒理学]