三种唇形科植物精油对水杨酸透皮促渗效果的研究  

Study on Transdermal Permeability of Salicylic Acid by Essential Oil from Three Labiatae Plants

作　　者：李琦苒 李锐扬 郭文 赵春雪 赵平艳 王国莉 杨猛 李琛 LI Qi-ran;LI Rui-yang;GUO Wen;ZHAO Chun-xue;ZHAO Ping-yan;WANG Guo-li;YANG Meng;LI Chen(School of Chemistry,Biology and Environment,Yuxi Normal University,Yunnan Yuxi 653100;School of Physics and Electronic Engineering,Yuxi Normal University,Yunnan Yuxi 653100,China)

机构地区：[1]玉溪师范学院化学生物与环境学院,云南玉溪653100 [2]玉溪师范学院物理与电子工程学院,云南玉溪653100

出　　处：《广州化工》2023年第22期58-60,共3页GuangZhou Chemical Industry

基　　金：玉溪师范学院大学生创新创业训练计划项目(2021A021、202011390032);云南省科技厅地方本科高校(部分)基础研究联合专项青年项目(202001BA070001-110);云南省高校特色植物化学评价及应用科技创新团队支持计划。

摘　　要：采用Franz扩散池,用猪皮模拟人皮肤对水杨酸的透皮吸收,利用紫外可见分光光度计测定水杨酸的透皮率,考察三种唇形科植物精油对水杨酸的透皮促渗效果。实验结果表明:在水杨酸透皮时间为24 h、精油含量为4%的最佳实验条件下,罗勒精油、百里香精油及迷迭香精油的水杨酸透皮率分别为1.200%、1.159%、0.993%,而空白对照组水杨酸的透皮率仅为0.373%,表明三种唇形科植物精油对水杨酸均具有良好的透皮促渗效果。The percutaneous absorption of salicylic acid by human skin was simulated by Franz diffusion pool with pig skin.The transdermal rate of salicylic acid was determined by UV-visible spectrophotometer.The transdermal permeability of salicylic acid was investigated by three essential oils of Labiaceae.The results showed that under the optimal experimental conditions of 24 h salicylic acid transdermal time and 4%essential oil content,the transdermal rates of basil essential oil,thyme essential oil and rosemary essential oil were 1.200%,1.159%and 0.993%,respectively,while the transdermal rates of blank control group were only 0.373%.The results showed that all the three essential oils of Labiaceae had good transdermal and osmotic effects on salicylic acid.

关 键 词：水杨酸 植物精油 透皮吸收促进剂 FRANZ扩散池 

分 类 号：O652.1[理学—分析化学]