基于Cu-TCPP的高灵敏5—羟色胺电化学检测新方法  

Novel electrochemical detection method for highly sensitive 5—HT based on Cu-TCPP

作　　者：彭连晖 王岐 姬柳迪 胡鹏 PENG Lianhui;WANG Qi;JI Liudi;HU Peng(College of Pharmacy,Hubei University of Science and Technology,Xianning 437100,China;Hubei Key Laboratory of Radiation Chemistry and Functional Materials,Xianning 437100,China;Hubei Collaboration Innovation Center of Non-power Nuclear Technology,Hubei University of Science and Technology,Xianning 437100,China)

机构地区：[1]湖北科技学院药学院,湖北咸宁437100 [2]辐射化学与功能材料湖北省重点实验室,湖北咸宁437100 [3]湖北科技学院非动力核技术研发中心,湖北咸宁437100

出　　处：《传感器与微系统》2024年第4期161-164,共4页Transducer and Microsystem Technologies

基　　金：国家自然科学基金资助项目(62001159);辐射化学与功能材料湖北省重点实验室专项基金重点资助项目(2021ZX07)。

摘　　要：以5,10,15,20—四(4—羧基苯基)卟啉(H_2TCPP)为配体,Cu~(2+)为金属中心源,通过液相剥离法制备了金属有机框架(MOFs)材料Cu-TCPP纳米片。制备Cu-TCPP纳米片修饰玻碳电极(Cu-TCPP/GCE),用于5—羟色胺(5—HT)的高灵敏检测。实验结果表明,与裸玻碳电极(GCE)相比,5—HT在Cu-TCPP/GCE上的氧化电流显著增强。通过研究其信号增强机理发现,Cu-TCPP纳米片可有效提高对5—HT的富集效率和电子转移能力。进一步对检测条件进行优化,成功建立了一种高灵敏的5—HT电化学检测新方法,线性范围为5~1 000 nmol/L,检出限为1.33 nmol/L。Metal organic frameworks(MOFs)material Cu-TCPP nanosheets are prepared by liquid-phase stripping method using 5,10,15,20—tetra-(4—carboxyphenyl)porphyrin(H2 TCPP)as ligand and Cu2+as metal center source.The Cu-TCPP nanosheets modified electrodes(Cu-TCPP/GCEs)are prepared and used in the highly sensitive determination of 5—HT.Compared with bare glassy carbon electrode(GCE),the oxidation current of 5—HT on Cu-TCPP/GCE is significantly increased.The signal enhancement mechanism is researched,and the Cu-TCPP nanosheets effectively improve the enrichment efficiency and electron-transfer-ability of 5—HT.By optimizing the detection conditions,a novel highly sensitive 5—HT electrochemical detection method is successfully established.The linear range is 5~1000 nmol/L,with the detection limit of 1.33 nmol/L.

关 键 词：铜—5—10 15 20—四(4—羧基苯基)卟啉 5—羟色胺 电化学传感器 增敏机理 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TB383[自动化与计算机技术—控制科学与工程]