基于滋水涵木法联合导入不同浓度的氨甲环酸溶液治疗女性黄褐斑疗效评价  

Evaluation of the therapeutic effect of different concentrations of tranexamic acid solution in the treatment of female melasma based on Zishui Hanmu method

作　　者：齐志峰[1] 姜亚楠 陈丽云 郑双进[1] 姚莹[1] 居兴刚[1] QI Zhifeng;JIANG Yanan;CHEN Liyun;ZHENG Shuangjin;YAO Ying;JU Xinggang(Dermatology Hospital,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第二附属医院皮肤病医院,河南洛阳471000

出　　处：《延安大学学报（医学科学版）》2024年第1期34-38,共5页Journal of Yan'an University:Medical Science Edition

摘　　要：目的观察基于“滋水涵木法”指导下的杞黄口服液联合导入不同浓度的氨甲环酸溶液治疗黄褐斑的有效性和安全性。方法选取河南科技大学第二附属医院皮肤科门诊2021年1月至2022年12月就诊的120例黄褐斑志愿者,随机分为3组,每组40例。C组口服维生素C片、维生素E软胶囊、杞黄口服液;B组在C组基础上同时用滚针导入5%氨甲环酸溶液,2次/月;A组在C组基础上同时导入10%氨甲环酸溶液,2次/月;3组疗程均为3个月。治疗前后进行黄褐斑面积及严重程度评分(melasma area severity index,MASI)、皮肤图像检测评分、氧化应激指标[血清丙二醛(Maleic dialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、超氧化物歧化酶(superoxide dismutase,SOD)]水平。结果A组有效率为87.5%,B组有效率为67.5%,C组有效率为52.5%,3组比较差异有统计学意义(P<0.05);3组治疗后,MASI评分、皮肤图像检测评分、MDA水平均下降,GSH-Px、SOD水平升高(P<0.05),组间比较,A组优于B组,B组优于C组(P<0.05)。结论导入高、低浓度氨甲环酸溶液组、杞黄口服液组均可治疗黄褐斑,但导入10%氨甲环酸溶液组能更有效地治疗黄褐斑,提高GSH-Px、SOD,降低MDA,改善MASI,在皮肤图像检测中,肉眼可见斑点、紫外线斑、红区均能改善,安全性较高。Objective To observe the efficacy and safety of Qihuang oral liquid under the guidance of"Zishui Hanmu method"in the treatment of melasma with different concentrations of tranexamic acid solution.Methods A total of 120 volunteers with melasma were selected from the dermatology clinic of the Second Affiliated Hospital of Henan University of Science and Technology from January 2021 to December 2022.They were randomly divided into three groups with 40 cases in each group.Group C took vitamin C tablets,vitamin E softgel,Qihuang oral liquid;Group B was given 5%tranexamic acid solution on the basis of group C,twice a month;Group A was given 10%tranexamic acid solution on the basis of group C,twice a month.The treatment course of the three groups was 3 months and melasma area severity index(MASI),skin image detection score,oxidative stress index maleic dialdehyde(MDA),glutathione peroxidase(GSH-Px)and superoxide dismutase(superoxide dismutase,SOD)levels were measured.Results The effective rate was 87.5%in group A,67.5%in group B and 52.5%in group C,and the difference was statistically significant(P<0.05).After treatment,MASI scores,skin image detection scores and MDA scores were all decreased,while GSH-Px and SOD scores were increased(P<0.05).Inter group comparison,group A was superior to group B and group B was superior to group C(P<0.05).Conclusion Both high or low concentration tranexamic acid solution group and Qihuang oral liquid group could treat melasma.However,the introduction of 10%tranexamic acid solution group can more effectively treat melasma,increase GSH-Px and SOD,reduce MDA,and improve MASI.In skin image detection,visible spots,ultraviolet spots,and red areas can be improved with high safety.

关 键 词：滋水涵木法 杞黄口服液 黄褐斑 氨甲环酸溶液 

分 类 号：R275[医药卫生—中医皮科] R758.42[医药卫生—中医学]