椎体骨折合并活化部分凝血活酶时间延长1例  

Vertebral fractures combined with prolonged activated partial prothrombin time:A case report

作　　者：白心竹 何金徽 陆松松[3] 李春[4] 王依林[1] 熊建[1] BAI Xinzhu;HE Jinhui;LU Songsong;LI Chun;WANG Yilin;XIONG Jian(Department of Trauma and Orthopaedics,Peking University People’s Hospital,National Center for Trauma Medicine,Beijing 100044,China;Department of Trauma,Zhejiang Provincial People’s Hospital Bijie Hospital,Bijie 551799,Guizhou,China;Department of Clinical Laboratory,Peking University People’s Hospital,Beijing 100044,China;Department of Rheumatology and Immunology,Peking University People’s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院创伤骨科,国家创伤医学中心,北京100044 [2]浙江省人民医院毕节医院创伤科,贵州毕节551799 [3]北京大学人民医院检验科,北京100044 [4]北京大学人民医院风湿免疫科,北京100044

出　　处：《北京大学学报（医学版）》2024年第2期371-374,共4页Journal of Peking University:Health Sciences

摘　　要：随着骨质疏松症发病率的逐年上升,骨质疏松性椎体压缩性骨折的发病率也逐渐增高[1]。自身免疫病患者由于疾病本身特点以及长期使用糖皮质激素治疗,会影响患者的骨形成和骨吸收[2],继而出现严重的继发性骨质疏松症,因而发生骨质疏松性椎体骨折的风险更高[3]。With the development of modern medical standards,autoimmune diseases and their associated successive osteoporosis have received increasing attention in recent years.Patients with autoimmune diseases,due to the characteristics of the disease and the prolonged use of glucocorticoid hormone therapy,may affect the bone formation and bone absorption of the patient,followed by severe successive osteoporosis,thereby increasing the risk of osteoporotic vertebral fractures.Vertebral compression fractures of the spine are common fracture types in patients with osteoporotic fractures.Osteoporosis is a common complication after glucocorticoid therapy in patients with autoimmune diseases.Percutaneous vertebroplasty(PVP)and percutaneous kyphoplasty(PKP)are minimally invasive operation and are commonly used surgical methods for the treatment of osteoporotic vertebral compression fractures.However,due to the operation of spinal puncture during the operation,there are serious surgical risks such as bone cement leakage,spinal epidural hemorrhage,subdural hemorrhage,and subarachnoid hemorrhage in both PVP and PKP.As a result,it is necessary to evaluate the patient’s body before surgery carefully,especially in the case of blood coagulation.This article reports a case of autoimmune disease patient admitted to Peking University People’s Hospital due to lumbar 4 vertebral compression fracture combined with Sj gren’s syndrome.The patient’s preoperative examination showed that the activated partial thromboplastin time(APTT)was significantly prolonged.After completing the APTT extended screening experiment and lupus anticoagulant factor testing,the multi-disciplinary team(MDT)of Peking University People’s Hospital jointly discussed the conclusion that the patient’s test results were caused by an abnormal self-immunity anti-copulant lupus(LAC).Based on the results of the laboratory examination,the patient was considered to be diagnosed with combined antiphospholipid syndrome(APS).For such patients,compared with the patient’s

关 键 词：椎体压缩性骨折 狼疮抗凝物 活化部分凝血活酶时间 骨质疏松 

分 类 号：R683.2[医药卫生—骨科学]