铁死亡在非小细胞肺癌中的作用及中药干预进展  

Role of Ferroptosis in Non-small Cell Lung Cancer and Progress of Traditional Chinese Medicine Intervention

作　　者：郭晓琦 王天琪 夏金婵[1] 曾华辉[2] 石文博[1] Xiaoqi GUO;Tianqi WANG;Jinchan XIA;Huahui ZENG;Wenbo SHI(Medical College,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Academy of Chinese Medicine,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学医学院,郑州450046 [2]河南中医药大学中医药科学院,郑州450046

出　　处：《中国肺癌杂志》2024年第3期216-230,共15页Chinese Journal of Lung Cancer

基　　金：河南省科技发展计划项目(No.222300420482)资助。

摘　　要：非小细胞肺癌(non-small celllung cancer,NSCLC)是全球发病率和死亡率较高的恶性肿瘤之一。铁死亡是铁依赖性活性氧(reactive oxygen species,ROS)异常堆积导致脂质过氧化而引起的新型细胞程序性死亡方式,涉及铁代谢、脂质代谢、氧自由基反应与脂质过氧化之间的平衡。近年来研究发现铁死亡与NSCLC发生发展密切相关。由于NSCLC治疗过程中化疗耐药及放疗抵抗等的出现,迫切需要开发新的有效药物和治疗策略,中药具有靶点多、副作用小等特点,在防治NSCLC方面有独特的优势。本文综述了铁死亡在NSCLC中的作用机制,探讨中药活性成分、单味药及中药复方通过铁死亡干预NSCLC的研究现状,以期为铁死亡通路研究及中药靶向铁死亡防治NSCLC提供新的理论依据。Non-small cell lung cancer(NSCLC)is one of the malignant tumors with high morbidity and mortality worldwide.Ferroptosis is a new type of programmed cell death caused by abnormal accumulation of iron-dependent reactive oxygen species(ROS)leading to lipid peroxidation.It involves the balance between iron metabolism,lipid metabolism,oxy-gen free radical reaction and lipid peroxidation.Recent studies have found that ferroptosis is closely related to the occurrence and development of NSCLC.Due to the emergence of chemotherapy resistance and radiotherapy resistance in the treatment of NSCLC,there is an urgent need to develop new effective drugs and treatment strategies.Traditional Chinese medicine has unique advantages in the prevention and treatment of NSCLC due to its multi-targets and minimal side effects.In this review,we summarize the mechanism of ferroptosis in NSCLC,and discuss the research status of active ingredients of traditional Chinese medicine,single-herb traditional Chinese medicine and Chinese herbal compounds in the intervention of NSCLC through ferroptosis,in order to provide a new theoretical basis for the research of ferroptosis pathway and the prevention and treatment of NSCLC by targeted ferroptosis of traditional Chinese medicine.

关 键 词：肺肿瘤 铁死亡 中药 

分 类 号：R273[医药卫生—中西医结合]