成纤维细胞重编程与创面修复的研究进展  

Research progress of fibroblast reprogramming and wound repair

作　　者：刘高雨 罗鹏 史春梦 Gaoyu Liu;Peng Luo;Chunmeng Shi(Department of Military Rocket Army Medical Teaching and Research,Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学火箭军医学教研室,重庆400038

出　　处：《中华损伤与修复杂志（电子版）》2024年第2期176-179,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家自然科学基金重点项目(82030056);国家自然科学基金青年科学基金项目(82102341)。

摘　　要：皮肤创面是最常见的临床病症之一,其修复结局包括再生性修复和纤维化修复。纤维化修复作为成体组织器官最主要的修复形式,不仅会导致组织器官功能障碍,影响美观和身心健康,还加重了医疗经济负担。在创面修复中,如何抑制纤维化修复和促进再生性修复,进一步保持受伤皮肤的完整性和功能性一直是难题。近年来,干细胞和重编程技术的发展为再生领域带来了概念性的革新。其中,成纤维细胞的重编程为难愈性创面的再生修复提供了新的技术支持。本文将概述皮肤成纤维细胞的生物学特点,并重点综述成纤维细胞的重编程在创面修复中的研究进展。Skin wound is one of the most common clinical diseases,and the outcome of wound healing includes regenerative repair and fibrosis repair.As the leading form of adult tissue and organ repair,fibrosis repair,also known as scar repair,will not only lead to tissue and organ dysfunction of patients,affect the appearance and physical and mental health,but also increase the medical and economic burden of the country.Therefore,how to inhibit fibrosis repair and promote regenerative repairin wound healing,so as to further maintain the integrity and function of the injured skin has been a major problem of medicine.In recent years,the development of stem cells and reprogramming techniques has brought conceptual innovation to regenerative medicine.And fibroblast reprogramming provides a new technical support for regenerative repair of large area burn and severe trauma.In this paper,the biological characteristics of skin fibroblasts are summarized,and the recent research progress of fibroblast reprogramming in wound repair is reviewed.

关 键 词：成纤维细胞 细胞重新编程 创面愈合 再生性修复 

分 类 号：R641[医药卫生—外科学]