基于肠⁃脑⁃皮轴探讨特应性皮炎的发病机制及中医药治疗研究进展  

Research advances in the pathogenesis of atopic dermatitis and its treatment with traditional Chinese medicine based on the gut⁃brain⁃skin axis

作　　者：张曾燕 张汇源 关建华 陈云龙 ZHANG Zengyan;ZHANG Huiyuan;GUAN Jianhua;CHEN Yunlong(College of Graduate,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学研究生院,天津301617

出　　处：《沈阳药科大学学报》2024年第3期388-396,408,共10页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81903884);国家自然科学基金面上项目(82374114);天津市卫生健康委员会中医中西医结合科研课题(2023083);天津市教委科研计划项目(2018KJ003)。

摘　　要：特应性皮炎(atopic dermatitis,AD)是一种易反复发作的慢性过敏性皮肤疾病,其发病机制主要与遗传因素、环境因素、免疫因素息息相关。AD的发展与肠道菌群状态、心理神经状态存在密切联系,AD患者往往存在着肠道菌群结构和代谢物变化以及抑郁和自卑等现象。肠道菌群、神经系统以及皮肤三者间的相互联系称为“肠⁃脑⁃皮轴”。基于调节肠道菌群、调节神经内分泌系统以治疗皮肤疾病的研究不在少数,但详细作用机制尚不明确。中医药对肠道菌群、神经内分泌系统及皮肤免疫均具有较好的调节作用,但基于三者间相互关系(即肠⁃脑⁃皮轴)治疗AD的基础及临床研究尚缺乏,作用靶点尚不清晰。因此,本文根据肠道菌群失衡、神经内分泌功能紊乱在AD的发生、发展中的作用,探讨肠⁃脑⁃皮轴在AD发病机制的研究进展。同时,探讨中医药通过调节肠⁃脑⁃皮轴治疗AD的研究进展,以期为中医药治疗AD研究提供新思路。Atopic dermatitis(AD)is a chronic allergic skin disease that is prone to recurrence,and its pathogenesis is mainly related to genetic,environmental,and immune factors.The development of AD is closely related to the intestinal flora and psycho⁃psychiatric state.Changes in intestinal flora structure and metabolites are associated with depression and inferiority in AD patients.There is a special way of communication between gut flora,the nervous system,and skin,called the"gut⁃brain⁃skin axis".Many researches based on the regulation of intestinal flora and the nervous system for the treatment of skin conditions have been reported,but the potential mechanism of the gut⁃brain⁃skin axis is still unclear.Traditional Chinese medicine exerts a good regulatory effect on the intestinal flora,neuroendocrine system,and skin immunity.However,basic and clinical evidence on the treatment of AD based on the communication between gut flora,the nervous system,and skin conditions(i.e.intestine⁃brain⁃cutaneous axis)is still lacking,and the target of action is unclear.Therefore,this manuscript summarizes the research progress of the gut⁃brain⁃dermis axis in the pathogenesis of AD according to the roles of intestinal flora imbalance and neuroendocrine dysfunction in the occurrence and development of AD.Meanwhile,the research progress of AD treatment by Chinese medicine through regulating the gut⁃brain⁃skin axis is discussed,which will provide new insight for the research of AD.

关 键 词：特应性皮炎 肠⁃脑⁃皮轴 肠道菌群 神经内分泌系统 中医药 

分 类 号：R917[医药卫生—药物分析学]