多聚脱氧核糖核苷酸在组织修复中的应用进展  

Progress in the application of polydeoxyribonucleotide in tissue repair

作　　者：邱凡珊 王涵[1] 陈静静 赵琛玉 李佳琪 韩倩倩[1] QIU Fanshan#;WANG Han#;CHEN Jingjing;ZHAO Chenyu;LI Jiaqi;HAN Qianqian(National Institute for Food and Drug Control,Beijing 102629,China;School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国食品药品检定研究院,北京102629 [2]中国药科大学药学院,南京210000

出　　处：《中国药师》2024年第3期510-519,共10页China Pharmacist

基　　金：国家重点研发计划项目诊疗装备与生物医用材料专项(2022YFC2409802)。

摘　　要：多聚脱氧核糖核苷酸(PDRN)为低分子量的线性多聚核苷酸片段,是良好的组织修复效应的生物活性分子,主要提取来源为鱼类生殖细胞。研究报道以及临床结果显示,PDRN具有低免疫原性和低毒性。因此,在皮肤创面修复、角膜损伤、消化道损伤修复及骨损伤修复等组织修复中显示出很好的应用潜力。本文重点对PDRN在组织损伤和修复中的应用进展进行总结,全面探讨了PDRN在组织修复中的作用和研究机制,为组织修复材料的研究及开发提供理论支持。Polydeoxyribonucleotide(PDRN),a linear polyribonucleotide fragment with low molecular weigh,is known for its bioactivity and effective tissue healing,primarily extracted from fish germ cells.Reports and clinical findings have shown that PDRN has low immunogenicity and low toxicity,which shows potential application in tissue repair,such as skin wound,corneas,digestive tract,and bone injury repair.The article mainly focus on the application of PDRN in tissue injury and repair,and comprehensively discuss the role and mechanism of PDRN in tissue repair which provide theoretical support for the research and development of tissue repair materials.

关 键 词：多聚脱氧核糖核苷酸 生物活性分子 组织修复 

分 类 号：R318[医药卫生—生物医学工程]