嵌合抗原受体T细胞治疗并发人疱疹病毒6B脑炎1例的护理  

Care of a child with human herpesvirus-6B encephalitis after chimeric antigen receptor T-cell therapy

作　　者：杨懿 王俊霞 陈毓雯 张慧敏 王梦川 Yang Yi;Wang Junxia;Chen Yuwen;Zhang Huimin;Wang Mengchuan(State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Disease,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China;Tianjin Institutes of Health Science,Tianjin 301600,China)

机构地区：[1]中国医学科学院血液病医院(中国医学科学院血液学研究所)血液与健康全国重点实验室、国家血液系统疾病临床医学研究中心细、胞生态海河实验室,天津300020 [2]天津医学健康研究院,天津301600

出　　处：《中国实用护理杂志》2024年第9期687-692,共6页Chinese Journal of Practical Nursing

基　　金：天津市护理学会科研课题(tjhlky2023YB05)。

摘　　要：总结1例脐血干细胞移植后接受嵌合抗原受体T细胞治疗并发人疱疹病毒6B(HHV-6B)脑炎患儿的护理经验。患儿,女,4岁,2021年5月28日确诊为急性T淋巴细胞白血病。护理要点包括全面细致地鉴别观察症状,为早诊断早治疗提供信息;制订专项管理方案,实施个体化护理;制订共享决策沟通模式,预防院内继发性感染;以患儿为中心,做好腰椎穿刺护理;评估患儿及家属需求,疏解负面情绪;完善出院前准备,注重延续护理。经过积极的治疗和精心的护理,患儿病情好转出院。持续随访6个月,患儿为持续缓解状态,无不良后遗症,生活恢复正常。Summarizing the nursing experience of a child with HHV-6B encephalitis after umbilical cord blood transplantation and CAR-T therapy.The child was 4 years old and was diagnosed with acute T lymphocytic leukemia on May 28,2021.Nursing points:meticulously observe symptoms for early diagnosis and treatment;develop a specialized management plan,implement individualized care;enhance medication management to improve the quality of care;establish a shared decision-making communication model to prevent hospital-acquired infections;provide patient-centered care for lumbar puncture;assess the needs of the child and family,alleviate negative emotions;improve pre-discharge preparation,emphasize continuity of care.With proactive treatment and careful nursing,the child′s condition improved,and they were discharged.Follow-up for six months showed the child in a sustained remission state with no adverse sequelae,and normal life resumed.

关 键 词：脐血干细胞移植 脑炎 疱疹病毒6型 人 儿科学 嵌合抗原受体 

分 类 号：R473[医药卫生—护理学]