院内制剂红花浸提液在增强CT对比剂外渗中的应用效果  

Application Effect of In-hospital Preparation of Safflower Extract in Enhancing CT Contrast Agent Extravasation

作　　者：白娟[1] 张海宇 段世英 韩玫[2] 朱兴来 BAI Juan;ZHANG Haiyu;DUAN Shiying;HAN Mei;ZHU Xinglai(Health Examination Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Radiology Department,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Radiology Department,No.988 Hospital of the PLA Joint Logistics Support Force,Zhengzhou 450042,China)

机构地区：[1]河南中医药大学第一附属医院体检中心,河南郑州450000 [2]河南中医药大学第一附属医院放射科,河南郑州450000 [3]中国人民解放军联勤保障部队第九八八医院影像医学科,河南郑州450042

出　　处：《河南医学研究》2024年第6期1104-1107,共4页Henan Medical Research

基　　金：河南省中医药科学研究专项课题(2021JDZY067)。

摘　　要：目的本研究旨在探讨院内制剂红花浸提液在对比剂外渗治疗中的应用效果,并与硫酸镁湿敷治疗进行对比。方法由于部分患者对硫酸镁湿敷治疗不能耐受,本研究试图寻找一种有效的替代药物,因此本文纳入60例研究对象,分别接受红花浸提液(30例)和硫酸镁湿敷治疗(30例),并对治疗效果进行评估,对比治疗24 h、72 h、1周后临床总有效率、患肢肿胀值及疼痛等级评分的差异。结果红花浸提液治疗24 h、72 h、1周后临床总有效率分别为80.0%、90.0%、100.0%;硫酸镁湿敷治疗24 h、72 h、1周后临床总有效率分别为80.0%、86.6%、96.6%;红花浸提液各治疗时间点患肢肿胀值分别为(22.79±0.56)、(18.24±0.01)、(17.38±0.46)cm;硫酸镁湿敷各治疗时间点患肢肿胀值分别为(23.35±0.44)、(18.11±0.15)、(17.53±0.27)cm。红花浸提液各治疗时间点患肢疼痛等级评分分别为(8.34±0.04)、(4.81±0.31)、(3.68±0.51)分。硫酸镁湿敷各治疗时间点患肢疼痛等级评分分别为(8.22±0.01)、(4.78±0.15)、(3.56±0.06)分。两组治疗24 h、72 h、1周后临床总有效率、患肢肿胀值及疼痛等级评分差异无统计学意义(P>0.05)。结论在对硫酸镁湿敷不能耐受患者,可利用红花浸提液替代治疗,能达到相同临床效果。Objective This study aims to explore the clinical efficacy of in-hospital preparation of safflower extract in the treatment of contrast agent extravasation,and compare it with magnesium sulfate wet compress treatment.Methods Due to the intolerance of some patients to magnesium sulfate wet compress treatment,this study attempted to find an effective alternative drug.Therefore,this study included 60 study subjects who received safflower extract(30 cases)and magnesium sulfate wet compress treatment(30 cases),and evaluated the treatment effect.The differences in clinical total effective rate,limb swelling value and pain grade score after 24 hours,72 hours and 1 week of treatment were compared.Results After treatment with safflower extract for 24 hours,72 hours and 1 week,the total clinical effective rates were 80.0%,90.0%and 100.0%,respectively.The total clinical effective rates of magnesium sulfate wet compress treatment after 24 hours,72 hours and 1 week were 80.0%,86.6%and 96.6%,respectively.The swelling values of the affected limb at each treatment time point with safflower extract were(22.79±0.56),(18.24±0.01)and(17.38±0.46)cm,respectively.The swelling values of the affected limb at each treatment time point with magnesium sulfate wet compress were(23.35±0.44),(18.11±0.15),and(17.53±0.27)cm,respectively.The pain level scores of the affected limb at each treatment time point of safflower extract were(8.34±0.04),(4.81±0.31)and(3.68±0.51)points,respectively.The pain level scores of the affected limb at each treatment time point of magnesium sulfate wet compress were(8.22±0.01),(4.78±0.15)and(3.56±0.06)points,respectively.There was no statistically significant difference in clinical total effective rate,limb swelling value and pain level score between the two groups after 24 hours,72 hours and 1 week of treatment(P>0.05).Conclusion In patients who cannot tolerate magnesium sulfate wet compress,safflower extract can be used as a substitute for treatment,achieving the same clinical efficacy.

关 键 词：红花浸提液 临床疗效 对比剂外渗 

分 类 号：R445.3[医药卫生—影像医学与核医学]