含酮喹啉衍生物的合成与表征  

Synthesis and Characterization of Ketoquinoline Derivatives

作　　者：王雅弘 苏霄霖 张永吉 邝文慧 吴良光 张慧东 WANG Yahong;SU Xiaolin;ZHANG Yongji;KUANG Wenhui;WU Liangguang;ZHANG Huidong(Liaodong University,Dandong Liaoning 11800,China)

机构地区：[1]辽东学院化工与机械学院,辽宁丹东118000

出　　处：《辽宁化工》2024年第3期347-350,共4页Liaoning Chemical Industry

基　　金：辽东学院大学生创新创业项目。

摘　　要：以邻苯二甲酰亚胺为原料,与KOH反应合成了邻苯二甲酰亚胺钾,再与4-溴甲基喹啉-2-酮反应合成了4-邻苯二甲酰亚胺甲基喹啉-2-酮,最后和DMF反应即可得到4-胺甲基喹啉-2-酮。其间运用核磁、红外、质谱等手段对其结构进行表征。通过实验确定该反应的最佳条件,从而解决反应条件苛刻的缺点,进而降低成本,提高产率。Potassium phthalimide was synthesized from phthalimide by reaction with KOH,then 4-bromomethylquinoline-2-one was synthesized by reaction with 4-bromomethylquinoline-2-one,and finally 4-aminomethylquinoline-2-one was obtained by reaction with DMF.Its structure was characterized by nuclear magnetic resonance,infrared spectroscopy and mass spectrometry.The optimum conditions of the reaction were determined by experiments,so as to solve the shortcomings of harsh reaction conditions,reduce the cost and improve the yield.

关 键 词：4-胺甲基喹啉-2-酮 合成 表征 

分 类 号：O626[理学—有机化学]