应用ROC曲线分析外周血可溶性TNF受体、IL-15评估肺结核的预后价值  

Use ROC curves to analyze peripheral blood soluble TNF receptors and IL-15 to evaluate the prognostic value of tuberculosis

作　　者：张丹 孔维顺 Zhang Dan;Kong Weishun(Department of Clinical Laboratory,Zaozhuang Chest Hospital(Zaozhuang Tumor Hospital),Zaozhuang Shandong,277599,China;Department of Blood Management,Zaozhuang Chest Hospital(Zaozhuang Tumor Hospital),Zaozhuang Shandong,277599,China)

机构地区：[1]枣庄市胸科医院(枣庄市肿瘤医院)检验科,山东枣庄277599 [2]枣庄市胸科医院(枣庄市肿瘤医院)血液管理科,山东枣庄277599

出　　处：《中外女性健康研究》2024年第3期31-34,共4页Women＇s Health Research

摘　　要：目的:分析外周血可溶性肿瘤坏死因子受体(sTNFR)、白细胞介素-15(IL-15)评估肺结核的预后价值。方法:选定枣庄市胸科医院2022年1月至2023年8月就诊的150例肺结核患者,比较预后良好组与不良组的血清sTNFR-55、sTNFR-75、IL-15水平,多因素logistic回归分析肺结核患者预后不良的危险因素,并绘制受试者工作曲线,计算曲线下面积,分析血清sTNFR-55、sTNFR-75、IL-15对肺结核预后不良的预测效能。结果:预后不良组的血清sTNFR-55、sTNFR-75水平均低于预后良好组,血清IL-15水平高于预后良好组(P<0.05)。logistic回归分析,年龄、病变范围、血清sTNFR-55、sTNFR-75、IL-15是肺结核患者预后不良的危险因素(P<0.05)。血清sTNFR-55、sTNFR-75、IL-15联合检测灵敏度均高于单一检测(P<0.05),血清sTNFR-55、sTNFR-75、IL-15联合检测特异度与单一检测比较无差异(P>0.05)。结论:肺结核患者的血清sTNFR-55、sTNFR-75表达量较低,血清IL-15表达量较高,联合检测血清sTNFR-55、sTNFR-75、IL-15,可提高对患者预后的预测效能,具有一定的参考价值。Objective:To analyze the peripheral blood soluble tumor necrosis factor receptor(sTNFR)and interleukin-15(IL-15)to evaluate the prognostic value of tuberculosis.Methods:We selected 150 tuberculosis patients treated in the Zaozhuang Chest Hospital from January 2022 to August 2023,compared serum sTNFR-55,sTnFR-75,and IL-15 levels in the good and poor prognostic groups,analyzed the risk factors for poor prognosis in tuberculosis patients,and drew a subjects'working curve,calculated the area under the curve,and analyzed the predictive efficacy of serum sTNFR-55,sTNFR-75,and IL-15 on poor tuberculosis prognosis.Results:The levels of serum sTNFR-55 and sTNFR-75 in the poor prognosis group were lower than those in the good prognosis group,and the level of serum IL-15 was higher than that in the good prognosis group(P<0.05).According to logistic regression analysis,age,extent of lesion,serum sTNFR-55,sTnFR-75,and IL-15 are risk factors for poor prognosis in tuberculosis patients(P<0.05).The sensitivity of combined detection of serum sTNFR-55,sTNFR-75 and IL-15 was higher than that of single detection(P<0.05).The specificity of combined detection of serum sTNFR-55,sTNFR-75 and IL-15 was no difference from that of single detection(P>0.05).Conclusion:Serum sTnFR-55 and sTnFR-75 expression levels are low in tuberculosis patients,and serum IL-15 expression is high.Combined testing of serum sTNFR-55,sTnFR-75,and IL-15 can improve the predictive efficacy of patients and has certain reference value.

关 键 词：肺结核 可溶性肿瘤坏死因子受体 白细胞介素-15 

分 类 号：R521[医药卫生—内科学]