非洲猪瘟基因Ⅰ型/Ⅱ型重组病毒研究现状及思考  

Researches on African Swine Fever GenotypeⅠ/ⅡRecombinant Viruses and Relevant Considerations

作　　者：戈胜强[1,2,3] 沙洲 郑辉 刘春菊[1] 左媛媛[1] 胡永新[1] 王晓华 刘爽[1] 魏荣[1] 王志亮[1] Ge Shengqiang;Sha Zhou;Zheng Hui;Liu Chunju;Zuo Yuanyuan;Hu Yongxin;Wang Xiaohua;Liu Shuang;Wei Rong;Wang Zhiliang(China Animal Health and Epidemiology Center,Qingdao 266032,Shandong,China;Qingdao Key Laboratory of Modern Biotechnology and Animal Epidemic Research,Qingdao 266032,Shandong,China;Key Laboratory of Animal Bio safety Risk Warning,Prevention and Control(South China),Ministry of Agriculture and Rural Affairs,Qingdao 266032,Shandong,China)

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032 [2]青岛市现代生物工程及动物疫病研究重点实验室,山东青岛266032 [3]农业农村部动物生物安全风险预警及防控重点实验室(南方),山东青岛266032

出　　处：《中国动物检疫》2024年第3期68-72,共5页China Animal Health Inspection

基　　金：国家重点研发计划项目(2022YFD1800500)。

摘　　要：基因重组在非洲猪瘟病毒(ASFV)基因组间广泛存在,它是造成ASFV遗传多样性的原因之一。ASFV基因Ⅱ型毒株2018年传入我国,2021年国内又报道发现基因Ⅰ型毒株和基因Ⅰ型/Ⅱ型重组病毒。我国分离的ASFV基因Ⅰ型/Ⅱ型重组毒嵌合了两个基因型序列并部分整合了二者的生物学特性,毒力与基因Ⅱ型强毒株相当,某些致病指标甚至更高;基因Ⅱ型减毒活疫苗株不能对该重组毒株产生有效保护。该重组毒株在国内的流行演变可能会显著影响ASFV的进化方向,并对ASFV疫苗研究带来新的挑战。本文通过对国内ASFV基因Ⅰ型/Ⅱ型重组病毒进行综述,就相关研究进展进行总结归纳,以期为我国ASF防控提供参考。Genetic recombination is widely present in the genomes of African swine fever virus(ASFV),contributing to the genetic diversity of ASFV.ASFV genotype II strain was introduced to China in 2018,and genotype I andⅠ/Ⅱrecombinant viruses were detected and reported in 2021.The genotypeⅠ/Ⅱrecombinant strains isolated in China were characterized by a hybridization of two genotype sequences,merging their biological properties,and the virulence was comparable to the highly pathogenic genotype II strain(pig/HLJ/18),even with higher indicators of pathogenicity;pigs infected with the recombinant strains could not be protected by genotype II attenuated live vaccine strains.The evolution of ASFV might be influenced by the prevalence and evolution of these strains,posing new challenges to the development of ASFV vaccines.The information on domestic ASFV genotypeⅠ/Ⅱrecombinant viruses was reviewed,and relevant researches were summarized,with a view to providing a reference for future prevention and control of ASF in China.

关 键 词：非洲猪瘟 重组病毒 疫苗研发 

分 类 号：S852.65[农业科学—基础兽医学]