乙癸愈风汤治疗肝肾阴虚型帕金森病的临床效果及氧化应激水平分析  

Clinical Effect and Oxidative Stress Level of Yigui Yufeng Decoction in theTreatment of Parkinson's Disease of Liver and Kidney Yin Deficiency Type

作　　者：姜培培 施书梅 徐沛 JIANG Peipei;SHI Shumei;XU Pei(Hai'an Hospital of Traditional Chinese Medicine,Nantong 226600,China)

机构地区：[1]海安市中医院,江苏南通226600

出　　处：《中医药学报》2024年第4期76-80,共5页Acta Chinese Medicine and Pharmacology

基　　金：江苏省中医药局科技项目(YB2021066)。

摘　　要：目的:观察乙癸愈风汤治疗肝肾阴虚型帕金森病的临床效果及对氧化应激水平的影响。方法:选取2020年3月—2022年12月海安市中医院脑病科收治的90例肝肾阴虚型帕金森病患者,采用随机数字表法分为试验组和对照组,每组45例。试验组采用多巴丝肼片联合乙癸愈风汤治疗,对照组采用多巴丝肼片治疗,比较两组的临床疗效、血清炎症因子水平、血清神经递质水平、中医症状积分和不良反应等方面,探讨其应用价值。结果:试验组显效率和总有效率都高于对照组,差异具有统计学意义(P<0.05);两组治疗后的CAT、GSH-Px水平均高于治疗前(P<0.01),IL-6水平低于治疗前(P<0.01);试验组治疗后的CAT、GSH-Px水平均比对照组高(P<0.01),IL-6水平比对照组低(P<0.01);两组治疗后的5-HT、DA水平均高于治疗前(P<0.01),试验组治疗后的5-HT、DA水平均高于照组(P<0.01);两组治疗后的中医症状积分均比治疗前低(P<0.01),试验组低于对照组(P<0.01);试验组和对照组治疗后不良反应发病率均比较低,且二者差异无统计学意义(P>0.05)。结论:乙癸愈风汤治疗肝肾阴虚型帕金森病的临床效果较好,能够显著降低患者体内的氧化应激水平,且不良反应较少,可以在临床上推广使用。Objective:To investigate the clinical effect of Yigui Yufeng decoction(YYD)on Parkinson's disease of liver and kidney yin deficiency type and its impact on oxidative stress level.Methods:Ninety patients with Parkinson's disease of liver and kidney yin deficiency type admitted to the Department of Encephalopathy of Hai'an Hospital of Traditional Chinese Medicine from March 2020 to December 2022 were randomly divided into an experimental group and a control group,with 45 patients in each group.The experimental group was treated with levodopa and benserazide hydrochloride tablets combined with YYD,and the control group was treated with levodopa and benserazide hydrochloride tablets.The clinical efficacy,serum inflammatory factor levels,serum neurotransmitter levels,traditional Chinese medicine(TCM)symptom scores and adverse reactions of the two groups were compared to explore their application value.Results:The efficiency and total effective rate of the experimental group were higher than those of the control group,and the difference was statistically significant(P<0.05).The levels of CAT and GSH-Px after treatment were higher than before treatment(P<0.01),and the levels of IL-6 were lower than before treatment(P<0.01).After treatment,the CAT and GSH-Px levels in the experimental group were higher than those in the control group(P<0.01),and the IL-6 levels were lower than those in the control group(P<0.01).The levels of 5-HT and DA after treatment in both groups were higher than before treatment(P<0.01),and the levels of 5-HT and DA in the experimental group were higher than those in the control group(P<0.01).The scores of TCM symptoms in both groups were lower than before treatment(P<0.01),and the scores in the experimental group were lower than those in the control group(P<0.01).The incidence of adverse reactions after treatment was lower in the experimental group than those of the control group,but there was no statistical significance(P>0.05).Conclusion:Yigui Yufeng decoction has good clinical effect in the trea

关 键 词：乙癸愈风汤 肝肾阴虚 帕金森病 氧化应激 多巴丝肼 

分 类 号：R277.7[医药卫生—中医学]