聚氨酯/黑种草子伤口敷料的制备与性能表征  

Preparation and Characterization of Polyurethane/Nigella Sativa Seed Wound Dressing

作　　者：陈鹤鸣 胡娇 康花 于萍 程璐 王颖 CHEN Heming;HU Jiao;KANG Hua;YU Ping;CHENG Lu;WANG Ying(College of Textile and Fashion Design,Xinjiang University,Urumqi 830046,China)

机构地区：[1]新疆大学纺织与服装学院,乌鲁木齐830046

出　　处：《功能高分子学报》2024年第2期148-156,共9页Journal of Functional Polymers

基　　金：自治区自然科学基金面上项目(2021D01C059)。

摘　　要：利用静电纺丝技术制备了负载不同浓度黑种草子提取物(NSS)的聚氨酯(PU)纳米纤维膜(PU/NSS)。对该纳米纤维膜的力学性能、亲水性、溶胀性、透气性、抗氧化性、抗菌性以及细胞毒性进行了表征,探讨了其在伤口敷料领域的应用潜力。结果表明:PU/NSS纳米纤维膜的纤维直径随着NSS含量的增加而增大,且NSS的加入改善了PU纳米纤维膜的亲水性。另外,NSS中的活性成分使PU/NSS纳米纤维膜表现出优异的抗氧化性和抗菌性,可以有效避免伤口感染。细胞毒性试验结果证明PU/NSS纳米纤维膜具有良好的生物相容性。To prepare a new type of multi-functional medical dressing,polyurethane(PU) nanofiber membranes loaded with different mass fractions of Nigella sativa seed extract(NSS) were prepared by electrospinning method to explore their application potential in wound dressing.The mechanical properties,hydrophilicity,swelling property,air permeability,antioxidant property,antibacterial property and cytotoxicity of the nanofiber membranes were characterized.The experimental results showed that the fiber diameter of PU/NSS nanofiber membranes increased with the increase of NSS mass fractions.The addition of NSS improved the hydrophilicity of PU nanofiber membrane,and the water contact angle decreased from(124.65±0.96)° to(29.90±0.49)°.The flavonoids active substances in NSS made PU/NSS nanofiber membranes have excellent antioxidant and antibacterial properties.The scavenging rate of 2,2-diphenyl-1-picryl hydrazyl(DPPH) radical could be up to(59.98±0.86)%.The inhibition rates of E.coli and S.aureus were(99.08±0.38)% and(97.30±0.36)%,respectively.The cytotoxicity test results showed that PU/NSS nanofiber membranes had good biocompatibility.The PU/NSS nanofiber membranes prepared in this study are expected to be applied in the field of wound dressing.

关 键 词：静电纺丝 黑种草子 聚氨酯 伤口敷料 细胞毒性 

分 类 号：O63[理学—高分子化学]