基于精室理论研制的生精方治疗特发性弱精子症的临床疗效评价  

Clinical efficacy evaluation of treating idiopathic asthenospermia with the Shengjing prescription based on the Jingshi theory

作　　者：朱勇 马亮亮 曾庆琪 ZHU Yong

机构地区：[1]盐城市中医院,江苏盐城224001 [2]江苏省名中医曾庆琪教授工作室,江苏盐城224001

出　　处：《中医临床研究》2024年第7期77-80,共4页Clinical Journal Of Chinese Medicine

基　　金：江苏省老年医学临床技术应用研究项目培养对象(LR2021051);盐城市医学科技发展计划项目(YK2020043)。

摘　　要：目的:评价生精方治疗特发性弱精子症的临床疗效。方法:参照随机数字表法将125例特发性弱精子症(脾肾亏虚型)患者分为治疗组和对照组,其中治疗组煎服生精方,对照组口服左卡尼汀,两组均连续治疗12周。分别记录两组患者治疗前后的精子浓度、前向运动精子比例、精子DNA碎片率及中医证候评分,进行临床疗效评价。结果:治疗组59例、对照组55例最终纳入研究统计。治疗组总有效率为84.75%(50/59),对照组总有效率为67.27%(37/55)。治疗组精子浓度治疗前为(25.8±3.7)×10^(6)/mL,治疗后为(43.2±5.4)×10^(6)/mL;对照组治疗前为(25.2±3.3)×10^(6)/mL,治疗后为(31.3±4.6)×10^(6)/mL。治疗组前向运动精子的比例治疗前为(16.3±6.1)%,治疗后为(40.6±8.3)%;对照组治疗前为(15.9±5.8)%,治疗后为(21.5±5.5)%。治疗组精子DNA碎片率治疗前为(28.2±5.3)%,治疗后为(12.7±3.8)%;对照组治疗前为(27.8±5.7)%,治疗后为(23.8±4.4)%。治疗组治疗期间临床妊娠率为8.47%(5/59),对照组为1.82%(1/55)。两组患者的精液质量(精子的浓度、前向运动精子的比例、精子DNA碎片率等)与治疗前相比均有不同程度改善,其中治疗组要显著优于对照组。治疗组临床妊娠率亦显著优于对照组。结论:生精方能较好地改善脾肾亏虚型特发性弱精子症患者的精子质量、提高妊娠率,对于患者的临床症状亦有一定的改善作用,具有一定的推广应用价值。Objective:To evaluate the clinical efficacy of the Shengjing prescription(生精方)in the treatment of idiopathic asthenospermia.Methods:A total of 125 patients with idiopathic asthenospermia of spleen and kidney deficiency type were all randomly divided into the treatment group and the control group.The treatment group was given the Shengjing prescription andO the control group was treated with levocarnitine,all for 12 weeks.The sperm concentration,proportion of forward motile sperm,sperm DNA fragment rate and TCM syndrome score in the groups before and after treatment were recorded for clinical efficacy evaluation.Results:A total of 59 cases in the treatment group and 55 cases in the control group were finally included in the statistical study.The total effective rate was 84.75%(50/59)in the treatment group and 67.27%(37/55)in the control group.In terms of sperm concentration,in the treatment group before treatment,it was(25.8±3.7)×10^(6)/mL,after treatment,it was(43.2±5.4)×10^(6)/mL.In the control group before treatment,it was(25.2±3.3)×10^(6)/mL,after treatment,it was(31.3±4.6)×10^(6)/mL.In terms of the proportion of forward moving sperm,in the treatment group before treatment,it was(16.3±6.1)%,after treatment,it was(40.6±8.3)%,in the control group before treatment,it was(15.9±5.8)%,after treatment,it was(21.5±5.5)%.In terms of sperm DNA fragmentation rates,in the treatment group before treatment,it was(28.2±5.3)%,after treatment,it was(12.7±3.8)%,in the control group before treatment,it was(27.8±5.7)%,after treatment,it was(23.8±4.4)%.In terms of clinical pregnancy rates,it was 8.47%(5/59)in the treatment group,and 1.82%(1/55)in the control group.The sperm concentration,the proportion of forward motile sperm and the sperm DNA fragment rate in the two groups were all improved compared with those before treatment,and in the treatment group were significantly better than those in the control group.The clinical pregnancy rate in the treatment group was also significantly higher than that in the

关 键 词：特发性弱精子症 精室理论 生精方 脾肾亏虚 

分 类 号：R256.5[医药卫生—中医内科学]