藤石松的生物碱类成分研究  

Study on alkaloids of Lycopodiastrum casuarinoides

作　　者：陈烨琪 潘亚茹 卓越 张一帆 顾继洪 CHEN Yeqi;PAN Yaru;ZHUO Yue;ZHANG Yifan;GU Jihong(Science and technology innovation center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Guangdong Clinical Research Academy of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学科技创新中心,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405 [3]广东省中医临床研究院,广东广州510405

出　　处：《中草药》2024年第5期1460-1465,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(82104014);广州市基础与应用基础研究项目(2023A04J2478)。

摘　　要：目的研究藤石松Lycopodiastrum casuarinoides的生物碱类成分。方法利用多种色谱方法对藤石松总生物碱部位进行分离纯化。通过多种波谱技术以及单晶X-射线衍射鉴定化合物的结构。结果从藤石松全株植物中分离到11个化合物,分别鉴定为6-羟基-β-玉柏碱(1)、去-N-甲基-β-玉柏碱(2)、casuarine B(3)、石杉碱乙(4)、casuarinine B(5)、β-玉柏碱(6)、蛇足石杉碱(7)、N-demethylhuperzinine(8)、石杉碱丙(9)、8,15-dihydrohuperzinine(10)、casuarinine I(11)。结论化合物1为新的石松碱类化合物。Objective To study the alkaloids from Tengshisong[Lycopodiastrum casuarinoides(Spring)Holub].Methods The total alkaloid fraction of L.casuarinoides was separated and purified by various chromatographic techniques.The chemical structures were identified by comprehensive spectroscopy analysis and single crystal X-ray diffraction.Results A total of eleven compounds were isolated from the total alkaloid fraction of L.casuarinoideds,and the structures were identified as 6-hydroxy-β-obscurine(1),des-Nmethyl-β-obscurine(2),casuarine B(3),huperzine B(4),casuarinine B(5),β-obscurine(6),huperzinine(7),N-demethylhuperzinine(8),huperzine C(9),8,15-dihydrohuperzinine(10),and casuarinine I(11).Conclusion Compound 1 is a new Lycopodium alkaloid.

关 键 词：藤石松 石松碱 6-羟基-β-玉柏碱 去-N-甲基-β-玉柏碱 石杉碱乙 蛇足石杉碱 

分 类 号：R284.1[医药卫生—中药学]