亚磺酸内酯研究进展  

Research Progress on Sultine

作　　者：杨铃悦 李赟婷 舒超 Yang Lingyue;Li Yunting;Shu Chao(National Key Laboratory of Green Pesticide,College of Chemistry,Central China Normal University,Wuhan 430079)

机构地区：[1]华中师范大学化学学院绿色农药全国重点实验室,武汉430079

出　　处：《化学学报》2024年第2期171-189,共19页Acta Chimica Sinica

基　　金：国家自然科学基金(No.22301093);华中师范大学和武汉市科学技术局(No.20201037026)资助。

摘　　要：亚磺酸内酯化合物是一类有趣且重要的含硫杂环化合物,在医药、生物和材料科学方面具有重要的研究价值和应用潜力,也是有机合成中的关键中间体之一.由于合成方法的不足,此类化合物长久被忽视,发展缓慢,近期亚磺酸内酯重新引起了关注.因此,对亚磺酸内酯的合成方法、性能以及应用进行了系统的概述.最后,对亚磺酸内酯的发展现状进行总结和展望,以期为亚磺酸内酯的未来发展提供参考.Heterocycles are a highly valuable class of complex scaffolds that are involved in a various kind of well-known organic compounds of industrial and pharmacological importance.Sultine,an important class of sulfur-containing heterocy clic compounds,plays central roles in medicine,biology and material science.The sulfur atom in sultine is located at a vertex of a stable pyramid without identical substituents,making it a chiral center with potential applications in asymmetric synthe-sis.The asymmetry of sultine can be easily eliminated by oxidizing it into sultone.In addition,sultines have shown to be versatile intermediates in organic synthesis.They can act as useful synthons with hidden bifunctionality:opening the hetero cycle at the S-O bond leads to the simultaneous appearance of two functional groups in the product.Despite their potential,the chemical research of sultines have been long neglected and underdeveloped due to their inaccessibility.Only recently,some research groups have discovered protocols for the preparation of these heterocycles and explored their properties using methods such as visible light-induced radical homolytic substitution cyclization and radical polar crossover cyclization,and so on.It is worth noting that although sultines have been discussed in a few reviews,they are not systematic but very frag mentary.Owing to the increasing interest in studies on sultines and their transformations.The synthesis methods,physical properties and applications of sultines are systematically summarized in the past 130 years.The synthetic tactics are reviewed by highlighting their product diversity,selectivity and applicability,along with the mechanistic rationale where possible.Ad-ditionally,the chemical transformations of sultines,including photolysis,thermolysis,ring-opening reactions,oxida tion/reduction reactions,and rearrangement reactions,are demonstrated.The usefulness of sultines in synthesis,medicine and materials is described as well.Finally,the development status of sultine compounds is review

关 键 词：亚磺酸内酯 合成 性能 应用 

分 类 号：O626[理学—有机化学]