大蝎子草的化学成分研究  

Chemical Constituents of Girardinia diversifolia

作　　者：刘亚华 赵旭萍 黎廷楷 张敬杰 孙宜春 李慧馨 邹娟 LIU Ya-hua;ZHAO Xu-ping;LI Ting-kai;ZHANG Jing-jie;SUN Yi-chun;LI Hui-xin;ZOU Juan(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China;National Pharmaceutical Group(Guizhou)Tongjitang Pharmaceutical Co.,Ltd.,Guiyang 550009,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]国药集团(贵州)同济堂制药有限公司,贵州贵阳550009

出　　处：《中药材》2023年第8期1951-1955,共5页Journal of Chinese Medicinal Materials

基　　金：国药集团同济堂(贵州)技术服务项目(JS-YF-KY-201912015)。

摘　　要：目的:研究大蝎子草Girardinia diversifolia(Link)Friis的化学成分。方法:利用硅胶柱色谱、薄层色谱等对大蝎子草的化学成分进行分离纯化,并通过波谱数据及理化性质鉴定化合物结构。结果:从大蝎子草中分离得到20个化合物,分别鉴定为:委陵菜酸(1)、芹菜素-7-O-β-D-吡喃葡萄糖苷(2)、山柰酚-3-O-β-D-吡喃葡萄糖苷(3)、蔗糖(4)、β-谷甾醇(5)、邻苯二甲酸二戊酯(6)、秦皮素(7)、东莨菪内酯(8)、对羟基肉桂酸(9)、水杨酸(10)、香草醛(11)、丁二酸(12)、trans-3-dodecenedioic acid(13)、壬二酸(14)、6,9,10-trihydroxy-octadec-7-enoic acid(15)、(E,E)-9-oxooctadeca-10,12-dienoic acid(16)、1-hexadecanoyl propan-2,3-diol(17)、1-亚油酸甘油酯(18)、n-hexacos-5,8,11-trienoic acid(19)、二十六烷(20)。结论:除化合物5、8外,其余化合物均为首次从大蝎子草中分离得到。Objective:To study the chemical constituents of Girardinia diversifolia.Methods:The chemical constituents of the Girar-dinia diversifolia were isolated and purified by silica gel column chromatography,thin layer chromatography,etc.The structures of the compounds were identified by spectral data and physicochemical properties.Results:Twenty compounds were isolated from Girardinia diversifolia and identified as tormentic acid(1),apigenin-7-O-β-D-glucopyranoside(2),astragaline(3),sucrose(4),β-sitosterol(5),di-N-pentyl phthalate(6),fraxidin(7),scopoletin(8),p-hydroxy-cinnamic acid(9),salicylic acid(10),vanillin(11),succinic acid(12),trans-3-dodecenedioic acid(13),azelaic acid(14),6,9,10-trihydroxy-octadec-7-enoic acid(15),(E,E)-9-oxooctadeca-10,12-dienoic acid(16),1-hexadecanoyl propan-2,3-diol(17),1-linoleoylglycerol(18),n-hexacos-5,8,11-trienoic acid(19),hexacosane(20),respectively.Conclusion:Except compounds 5,8,other compounds are isolated from Girardinia diversifolia for the first time.

关 键 词：大蝎子草 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]