脂肪酸代谢重编程在肺纤维化中的研究进展  

Advances on reprogramming of fatty acid metabolism in pulmonary fibrosis

作　　者：白璐 王佳新 王雪[3] 曾巍 宋美月 张田甜[1] 王婧[1] BAI Lu;WANG Jiaxin;WANG Xue;ZENG Wei;SONG Meiyue;ZHANG Tiantian;WANG Jing(State Key Laboratory of Respiratory Health and Multimorbidity,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100005;Tsinghua-Peking Center for Life Sciences,Department of Biology,College of Medicine,Tsinghua University,Beijing 100084;Department of Respiratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]中国医学科学院基础医学研究所、北京协和医学院基础学院呼吸与共病全国重点实验室,北京100005 [2]清华大学医学院生物系生命科学中心,北京100084 [3]哈尔滨医科大学第二附属医院呼吸科,黑龙江哈尔滨150001

出　　处：《基础医学与临床》2024年第4期548-552,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(82300098);中央级公益性科研院所基本科研业务费(2022-RC310-06);中国医学科学院医学与健康科技创新工程(2021-I2M-1-049)。

摘　　要：肺纤维化是一类进行性间质纤维化性肺部疾病,死亡率高。其发病机制复杂,涉及脂肪酸的代谢重编程,包括脂肪酸的从头合成、摄取、氧化以及衍生物的改变。脂肪酸代谢重编程参与调控肺泡上皮细胞的生存状态、巨噬细胞极化类型以及成纤维细胞活化情况,发挥促进或者抑制肺纤维化的作用。通过判断或干预脂肪酸代谢重编程相关过程可以有效预防、诊断和治疗肺纤维化。Pulmonary fibrosis is a progressive interstitial fibrotic lung disease with high mortality.Its pathogenesis is complex and involves the reprogramming of fatty acid metabolism.This reprogramming includes changes in de novo fatty acid synthesis,uptake,oxidation,and derivatives.It crucially influences alveolar epithelial cell survival,macrophage polarization,and fibroblast activation,thereby playing a significant role in either exacerbating or mitigating the disease.Understanding and intervening in the reprogramming of fatty acid metabolism offers potential strategies for prevention,diagnosing and treatment of pulmonary fibrosis.

关 键 词：脂肪酸 肺纤维化 代谢重编程 

分 类 号：R563[医药卫生—呼吸系统]