A polyphenol-induced hydroxyapatite coating modulates corrosion resistance and biocompatibility of magnesium alloys  

作　　者：Tao Chai Hao Zhang Xiaolong Shen Haibo Wang Xingping Fan Binbin Wang Dingying He Jia Su 

机构地区：[1]Institute of Vanadium and Titanium,Panzhihua University,Panzhihua,China [2]Engineering Technology Research Center of Vanadium and Titanium Materials,Panzhihua University,Panzhihua,China [3]College of Biology&Chemical Engineering(Agricultural College),Panzhihua University,Panzhihua,China

出　　处：《Biosurface and Biotribology》2023年第4期129-141,共13页生物表面与生物摩擦学（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:52101286;Natural Science Foundation of Sichuan Province,Grant/Award Number:2022NSFSC2011;National College Student Innovation and Entrepreneurship Training Program,Grant/Award Number:202211360009。

摘　　要：In order to solve the problem of excessive degradation rate and insufficient biocom-patibility of magnesium-based bone implants,a polyphenol(EGCG)induced hydroxy-apatite(HA)coating was prepared on the surface of AZ31 alloy.The physical and chemical properties and corrosion resistance of the coating were analysed in depth,and its biocompatibility was preliminarily explored in vitro.The results showed that the polyphenol(EGCG)conversion coating constructed on the AZ31 could successfully induce the formation of HA by complexing the phenolic hydroxyl group with calcium ions.The electrochemical and long-term immersion experiments showed that the corrosion resistance of EGCG/HA composite coating was significantly improved.The self-corrosion current density,hydrogen evolution and the increase of pH value of AZ31-EGCG/HA were significantly lower than those of AZ31.On the basis of inhibiting the excessive corrosion of the substrate,the composite coating significantly improves the compatibility of pre-osteoblasts,supports the adhesion and spreading and effectively reduces the haemolysis rate to less than 5%.The preparation method of the coating is simple,low cost and suitable for complex shape surfaces,which can significantly improve the corrosion resistance and biocompatibility of the AZ31 substrate.It is expected to provide a solution for the surface modification of magnesium-based bone implants.

关 键 词：attrition-corrosion BIOCOMPATIBILITY 

分 类 号：TG146.22[一般工业技术—材料科学与工程]