Improving anti-Gram-positive-bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non-antibiotic lysozyme and parathyroid hormone  

作　　者：Deren Zhao Tianhao Chen Jinqian Chen Banglun Huang Jihua Nie Hulin Liu Yangkai Liu Zilin Chen Feng Zou Qiqi Lu Xiaodong Tan Yunjie Xiang Jing Li Yongping Zhang Xue Feng Xi Rao 

机构地区：[1]School of Materials and Energy,Southwest University,Chongqing,China [2]Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing,Southwest University,Chongqing,China [3]Department of Clinical Laboratory,University-Town Hospital of Chongqing Medical University,Chongqing,China

出　　处：《Biosurface and Biotribology》2023年第4期199-209,共11页生物表面与生物摩擦学（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Number:52271250;Venture and Innovation Support Program for Chongqing Overseas Returnees,Grant/Award Number:cx2021106;Natural Science Foundation of Chongqing Municipality,Grant/Award Number:CSTB2023NSCQ-MSX0977。

摘　　要：In this work,a novel coating with a non-antibiotic agent for inhibiting Gram-positive bacteria and promoting osteogenesis was prepared on zinc-aluminium alloy(ZA6-1)via mussel mimetic polydopamine(PDA)containing lysozyme(LYS)and parathyroid hormone(PTH).The results indicate that as-deposited coatings can efficiently decrease the degradation rate of ZA6-1 from 0.52 to 0.16 mm/year,and the addition of LYS weakens the coating resistance,while the addition of PTH enhances the coating resis-tance.In spite that no obvious inhibition of Escherichia coli is observed,the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus.Compared with ZA6-1 zinc alloys,the increase of antibacterial efficacy reaches 86.9%-90.1%.Furthermore,the lower hydrophilicity(26.4°),higher osteoblast cell viability(>100%),good osteoblast cell morphology and better osteoblast cell differentiation(ALP=107.7%)for PDA-LYS/PTH coated samples support that as-prepared coating is promising for modifying biodegradable zinc implants.

关 键 词：antibacterial biocompatibility non-antibiotic antimicrobial strategy 

分 类 号：TG146.13[一般工业技术—材料科学与工程]