基于专利数据分析热熔挤出技术在生物医药领域的应用  

Application of Hot Melt Extrusion Technology in Biomedicine Field Based on Patent Data

作　　者：师帅 赵迎春 林瑞红 李文刚 王烁 于婧 SHI Shuai;ZHAO Yingchun;LIN Ruihong;LI Wengang;WANG Shuo;YU Jing(Shenyang Intellectual Property Protection Center,Shenyang 110000,China;Shenyang Food and Drug Control Institute,Shenyang 110011,China)

机构地区：[1]沈阳市知识产权保护中心,沈阳110000 [2]沈阳市食品药品检验所,沈阳110011

出　　处：《生物技术进展》2024年第2期331-337,共7页Current Biotechnology

基　　金：辽宁省专利转化专项计划项目(2023-04-02)。

摘　　要：热熔挤出技术是指将药物、增塑剂和聚合物等辅料在熔融状态下混合后,以一定的压力、速度和形状挤出形成药物产品的技术,对于改善并提高药物溶解度、改进制备缓控制剂方法具有重要意义。以生物医药产业领域的热熔挤出专利为分析样本,采用专利数据库数据及“定量+定性”分析方法,从专利产出趋势、主要竞争力量、热点技术等方面分析热熔挤出技术在生物医药产业领域中的应用,以期为该领域的研究决策提供参考。Hot melt extrusion technology refers to the technology that drugs,plasticizers and polymers are mixed in the molten state and extruded to form drug products at a certain pressure,speed and shape,which is of great significance for improving and increasing the solubility of drugs and improving the preparation method of slow control agents.This paper took hot melt extrusion patents in pharmaceutical industry as analysis samples,adopted patent database data and qualitative analysis method to analyze the application of hot melt extrusion technology in pharmaceutical industry from the aspects of patent output trend,main competi‐tive forces,hot technologies,etc.,so as to provide reference for research decision-making in this field.

关 键 词：专利数据 热熔挤出技术 生物医药 

分 类 号：Q819[生物学—生物工程] R94[医药卫生—药剂学] G306[医药卫生—药学]