RNAi——对抗细菌耐药的新途径  

RNAi:A Novel Approach Against Bacterial Resistance

作　　者：曹文迪 黄乙财 徐天乐 Cao Wendi;Huang Yicai;Xu Tianle(Institutes of Agricultural Science and Technology Development,Yangzhou University,Yangzhou 225009,China;College of Animal Science and Technology,Yangzhou University,Yangzhou 225009,China)

机构地区：[1]扬州大学农业科技发展学院,江苏扬州225009 [2]扬州大学动物科学与技术学院,江苏扬州225009

出　　处：《农业科学研究》2024年第1期79-83,96,共6页Journal of Agricultural Sciences

基　　金：江苏省现代农业产业(奶牛)技术体系首席专家项目(JATS[2022]486);国家自然科学基金青年项目(32102731);教育部农业与农产品安全国际合作联合实验室开放课题(JILAR-KF202204)。

摘　　要：近年来细菌感染问题日益严重,给人类和畜禽带来极大的危害。当前治疗细菌感染的手段仍以使用抗生素为主,但抗生素的滥用会造成细菌耐药性的增强。RNAi的出现或许给治疗细菌感染带来希望,小分子RNA通过干扰耐药基因的合成阻止其耐药及增殖过程。目前该技术在哺乳动物的病毒感染研究中较为常见,且在治疗鱼类细菌感染中也有应用,但并未直接作用于特定抗生素耐药基因。阐明RNAi机制及其在防控耐药细菌感染方面的有关研究进展,进一步揭示该技术对抗耐药病原菌感染的可观前景。Bacterial infections have become increasingly serious in recent years,posing significant threats to humans and livestock.Antibiotics remain the primary means of treating bacterial infections,yet the use of antibiotics enhances bacterial resistance.The emergence of RNA interference(RNAi)may offer hope in treating bacterial infections,as small RNA molecules can block the synthesis of resistance genes,thereby preventing their resistance and proliferation.Currently,this approach is more commonly implemented in viral infection studies in mammals and is also applied in treating bacterial infections in fish,but it has not been directly targeted at specific antibiotic-resistant genes.This paper aims to elucidate the mechanism of RNAi and its progress in research related to the prevention and control of resistant bacterial infections,further revealing the promising prospects of this technology in combating resistant pathogenic infections.

关 键 词：RNA干扰技术 细菌感染 耐药性 

分 类 号：S859[农业科学—临床兽医学]