铜死亡与铜载体药物抗肿瘤机制的研究进展  

Research progress of cuprotosis and anticancer mechanism of copper carrier drugs

作　　者：蔡林峻 雷靖 刘文斐 钱莹莹 马吉勇[1] CAI Linjun;LEI Jing;LIU Wenfei;QIAN Yingying;MA Jiyong(Department of Respiratory and Critical Care Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,Jiangsu Province,China)

机构地区：[1]南京医科大学附属南京医院呼吸与危重症医学科,江苏南京210006

出　　处：《世界临床药物》2024年第2期181-186,共6页World Clinical Drug

摘　　要：铜参与诸多生命过程,铜稳态失衡会导致细胞死亡,该过程被称为铜死亡。肿瘤细胞为维持更高的细胞活性,铜负荷较高。利用铜载体及相关药物可以参与诱导肿瘤细胞的铜过载,引发肿瘤细胞铜死亡。现针对铜死亡与肿瘤的关系以及铜载体药物的抗肿瘤机制作一综述。Copper is involved in many life processes,and imbalance of copper homeostasis leads to cell death,a process known as copper death.Tumor cells maintained higher cellular activity and higher copper load.Copper carriers and related drugs can induce copper overload in tumor cells and lead to copper death of tumor cells.This article reviewed the relationship between copper death and cancer and the anticancer mechanism of copper carrier drugs.

关 键 词：铜死亡 铜代谢 肿瘤 氧化激活反应 细胞死亡 铜纳米 铜配合物 铜螯合剂 

分 类 号：R797.9[医药卫生—临床医学] R73