地佐辛在喉癌术后静脉自控镇痛中应用的前瞻性随机对照研究  

Application of dezocine in patient-controlled intravenous analgesia after laryngectomy:a prospective randomized controlled study

作　　者：易雯婧 万丽纯 潘昳婷 李杰 YI Wen-jing;WAN Li-chun;PAN Yi-ting;LI Jie(Department of Anesthesiology,Eye and ENT Hospital,Fudan University,Shanghai 200031,China)

机构地区：[1]复旦大学附属眼耳鼻喉科医院麻醉科,上海200031

出　　处：《复旦学报（医学版）》2024年第2期238-242,共5页Fudan University Journal of Medical Sciences

摘　　要：目的探讨不同剂量的地佐辛相比舒芬太尼在喉癌术后镇痛效果的差异。方法采用随机对照研究,将2022年2月至2023年1月择期行部分喉手术的129名患者随机分为地佐辛0.5 mg/kg组(D1组)、地佐辛0.6 mg/kg组(D2组)和舒芬太尼2μg/kg组(S组)。比较3组24 h镇痛泵用量,术后6、12、24和48 h的视觉模拟评分(visual analogue scale,VAS)和48 h自控镇痛(patient-controlled intravenous analgesia,PCIA)按压总次数,并记录两者术后的不良反应(恶心、呕吐、头晕、尿潴留和呼吸抑制)发生率。结果3组24 h镇痛泵用量无差异,术后6 h D1组VAS评分高于S组(P<0.05),12、24和48 h 3组VAS评分之间差异无统计学意义。3组在总按压次数和术后不良反应之间无明显差异。结论与应用舒芬太尼相比,0.6 mg/kg地佐辛可提供相同程度的镇痛效果,但并未发现可降低不良反应等优势。Objective To investigate different doses of the analgesic effects of dezocine comparing with sufentanil after laryngectomy.Methods A total of 129 patients who underwent elective partial laryngectomy from Feb 2022 to Jan 2023 were randomly assigned to dezocine 0.5 mg/kg group(group D1),dezocine 0.6 mg/kg group(group D2)and sufentanil 2μg/kg group(group S).Twenty-four hours amount of drugs,the visual analogue scale(visual analogue scale,VAS)and 48 h total pressing times of PCA(patient-controlled intravenous analgesia,PCIA)were compared among the three groups at 6,12,24 and 48 h after operation,and the postoperative adverse reactions(nausea,vomiting,dizziness,urinary retention and respiratory depression)were recorded.Results There was no significant difference in 24 h amount of drugs among the three groups.The VAS score of group D1 was higher than that of group S at 6 h postoperatively(P<0.05),but did not differ significantly among the three groups at 12,24 and 48 h.There was no significant differences in the number of compressions and postoperative adverse reactions among the three groups.Conclusion Compared with sufentanil,0.6 mg/kg dezocine can provide the same degree of analgesic effect.However,no advantage was found to reduce adverse reactions.

关 键 词：地佐辛 舒芬太尼 术后镇痛 喉切手术 

分 类 号：R614.1[医药卫生—麻醉学]