NT-proBNP联合心脏超声在婴儿充血性先心病心功能评估中的应用  

Application of NT-proBNP combined with echocardiography in the evaluation of cardiac function in infants with congestive congenital heart disease

作　　者：刘红霞[1] 卢文青[1] 陈丽萍[1] 俞波[1] 郭晨[1] LIU Hongxia;LU Wenqing;CHEN Liping;YU Bo;GUO Chen(Department of Neonatology,Jiangxi Children's Hospital,330006)

机构地区：[1]江西省儿童医院新生儿科,南昌330000

出　　处：《江西医药》2023年第12期1399-1401,1410,共4页Jiangxi Medical Journal

基　　金：江西省卫计委科技计划课题,编号20171129。

摘　　要：目的探讨血清脑钠肽前体(NT-proBNP)在充血性先心病患儿心功能评估中的意义。方法研究2016年6月至2022年10月入住我院新生儿科、小儿心脏病治疗中心充血性先心病患儿46例;根据Ross分级分为HF组与非HF组,其中非HF组20例,HF组26例。两组患儿入院后均给予抗感染、吸氧、强心、利尿等相应处理,并测定其治疗前及治疗7天后血清NT-proBNP水平及左心室射血分数(LVEF)、左室舒张末期短轴缩短率(LVFS),分析两组患儿治疗前后血清NT-proBNP浓度和LVEF、LVFS变化及相关性。结果HF组与非HF组比较,血清NT-proBNP(1567.58±320.37)pg/mL升高,LVEF(54.31±3.78)%及LVFS(28.56±2.03)%均降低,差异有统计学意义(P<0.05);治疗前后比较:患儿治疗后血清NT-proBNP浓度(534.18±19.17)pg/mL下降,LVEF(63.11±10.21)%及LVFS(39.26±8.12)%均升高,差异有统计学意义(P<0.05);血清NT-proBNP水平与LVEF、LVFS呈负相关(r=-0.667,r=-0.509,P<0.05)。结论表达血清NT-proBNP水平在心功能不全时有明显升高,联合LVEF、LVFS对心衰的诊断及治疗随访中有一定指导意义。Objective To investigate the significance of serum brain natriuretic peptide precursor(NT-proBNP)in the evaluation of cardiac function in children with congestive congenital heart disease.Methods From June 2016 to October 2022,46 children with congestive congenital heart disease admitted to neonatology department and pediatric cardiology treatment Center of our hospital were collected.According to Ross classification,they were divided into HF group and non-HF group,including 20 cases in non-HF group and 26 cases in HF group.After admission,the children in both groups were given anti-infection,oxygen inhalation,cardiac strength,diuresis and other corresponding treatments,and the serum level of NT-proBNP,left ventricular ejection fraction(LVEF)and left ventricular end-diastolic short-axis shortening rate(LVFS)were measured before treatment and 7 days after treatment.The changes of serum NT-proBNP concentration,LVEF and LVFS before and after treatment and their correlation were analyzed.Results Compared with non-HF group,serum NT-proBNP(1567.58±320.37)pg/mL was increased,LVEF(54.31±3.78)%and LVFS(28.56±2.03)%were decreased,the difference was statistically significant(P<0.05);Comparison before and after treatment:serum NT-proBNP concentration(534.18±19.17)pg/mL decreased after treatment,LVEF(63.11±10.21)%and LVFS(39.26±8.12)%increased,the difference was statistically significant(P<0.05);Serum NT-proBNP level was negatively correlated with LVEF and LVFS(r=-0.667,r=-0.509,P<0.05).Conclusion The level of serum NT-proBNP increases significantly in patients with cardiac insufficiency.The combination of LVEF and LVFS has certain guiding significance in the diagnosis and treatment of heart failure.

关 键 词：血清脑钠肽前体 左心室射血分数 左室舒张末期短轴缩短率 心功能评估 

分 类 号：R725.4[医药卫生—儿科]