宣肺平喘汤联合孟鲁斯特钠治疗支气管哮喘的临床疗效及对患者血清学指标的影响  

Clinical efficacy of Xuanfei Pingchuan decoction combined with montelukast sodium in the treatment of bronchial asthma and its influence on serological indexes of patients

作　　者：李爱霞 徐峰 LI Aixia;XU Feng(Department of Pulmonary Diseases and Critical Care Medicine,Xianning Hospital of Traditional Chinese Medicine,Xianning,Hubei,437100,China;Department of Neurosurgery,Xianning Central Hospital/the First Affiliated Hospital of Hubei University of Science and Technology,Xianning,Hubei,437100,China)

机构地区：[1]咸宁市中医医院肺病科与重症医学科,湖北咸宁437100 [2]咸宁市中心医院/湖北科技学院第一附属医院神经外科,湖北咸宁437100

出　　处：《当代医学》2024年第1期14-18,共5页Contemporary Medicine

摘　　要：目的探讨宣肺平喘汤联合孟鲁斯特钠治疗支气管哮喘(BA)的临床疗效及对患者血清学指标的影响。方法选取2019年10月至2021年10月咸宁市中医医院收治的90例BA患者作为研究对象,按照随机数字表法分为对照组(行孟鲁斯特钠治疗)与观察组(行宣肺平喘汤+孟鲁斯特钠治疗),每组45例。比较两组血清学指标[嗜酸性粒细胞阳离子蛋白(ECP)、肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)]、肺功能指标[呼气峰值流速(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))]、中医证候积分、免疫功能、临床疗效。结果治疗后,两组ECP、TNF-α、IL-8水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组PEF均快于治疗前,FVC、FEV_(1)均大于治疗前,且观察组PEF快于对照组,FVC、FEV_(1)均大于对照组,差异有统计学意义(P<0.05)。治疗后,两组胸闷、咳嗽、气促评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CD8^(+)水平均低于治疗前,CD4^(+)水平、CD4^(+)/CD8^(+)均高于治疗前,且观察组CD8^(+)水平低于对照组,CD4^(+)水平、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为93.33%,高于对照组的75.56%,差异有统计学意义(P<0.05)。结论宣肺平喘汤联合孟鲁斯特钠治疗BA患者疗效显著,可改善患者血清学指标和肺功能,缓解症状,提高免疫功能,值得临床推广应用。Objective To explore the clinical efficacy of Xuanfei Pingchuan decoction combined with montelukast sodium in the treatment of bronchial asthma(BA)and its influence on the serological indexes of patients.Methods 90 patients with BA in Xianning Hospital of Traditional Chinese Medicine from October 2019 to October 2021 were selected as the research subjects,and they were divided into the control group(treated with montelukast sodium)and the observation group(treated with Xuanfei Pingchuan decoction combined with montelukast sodium)according to the random number table method,with 45 cases in each group.The serological indexes(eosinophil cationic protein[ECP],tumor necrosis factor-α[TNF-α]and interleukin-8[IL-8]),lung function indexes(peak expiratory flow[PEF],forced vital capacity[FVC],forced expiratory volume in one second[FEV_(1)]),Traditional Chinese Medicine syndrome score,immune function and clinical efficacy were compared between the two groups.Results After treatment,the levels of ECP,TNF-αand IL-8 of the two groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,PEF of the two groups was faster than that before treatment,FVC and FEV_(1) were greater than before treatment,and PEF in the observation group was faster than the control group,FVC and FEV_(1) were greater than the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of chest tightness,cough and shortness of breath of the two groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,CD8^(+)level of the two groups were lower than before treatment,CD4^(+)level and CD4^(+)/CD8^(+)were higher than those before treatment,and CD8^(+)level in the observation group was lower than that in the control group,while CD4^(+)level and CD4^(+)/CD8^(+)were higher than those

关 键 词：宣肺平喘汤 孟鲁斯特钠 支气管哮喘 嗜酸性粒细胞阳离子蛋白 肿瘤坏死因子Α 

分 类 号：R562.25[医药卫生—呼吸系统]