The diverse landscape of AB5-type toxins  

作　　者：Paris I.Brown Adaobi Ojiakor Antonio J.Chemello Casey C.Fowler 

机构地区：[1]Department of Biological Sciences,University of Alberta,Edmonton,AB T6G2E9,Canada

出　　处：《Engineering Microbiology》2023年第4期90-104,共15页工程微生物学（英文）

基　　金：supported by a start-up grant provided by the Uni-versity of Alberta Faculty of Science(to C.C.F.);a Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant(Grant number:RGPIN-2020-03964 to C.C.F.).

摘　　要：AB_(5)-type toxins are a group of secreted protein toxins that are central virulence factors for bacterial pathogens such as Shigella dysenteriae,Vibrio cholerae,Bordetella pertussis,and certain lineages of pathogenic Escherichia coli and Salmonella enterica.AB_(5) toxins are composed of an active(A)subunit that manipulates host cell biology in complex with a pentameric binding/delivery(B)subunit that mediates the toxin’s entry into host cells and its subsequent intracellular trafficking.Broadly speaking,all known AB_(5)-type toxins adopt similar structural architectures and employ similar mechanisms of binding,entering and trafficking within host cells.Despite this,there is a remarkable amount of diversity amongst AB_(5)-type toxins;this includes different toxin families with unrelated activities,as well as variation within families that can have profound functional consequences.In this review,we discuss the diversity that exists amongst characterized AB_(5)-type toxins,with an emphasis on the genetic and functional variability within AB_(5) toxin families,how this may have evolved,and its impact on human disease.

关 键 词：Bacterial pathogenesis Pathogen evolution Ab-type toxins Ab5-type toxins Shiga toxin Cholera toxin Heat-labile toxin Pertussis toxin Typhoid toxin ArtAB toxin 

分 类 号：Q93[生物学—微生物学]