Nanostructured boron agents for boron neutron capture therapy:a review of recent patents  

作　　者：Xiyin Zhang Yusheng Lin Narayan SHosmane Yinghuai Zhu 

机构地区：[1]Shenzhen HEC Industrial Development Co.,Ltd.,Shenzhen,Guangdong Province,China [2]Department of Chemistry and Biochemistry,Northern Illinois University,DeKalb,IL,USA [3]Sunshine Lake Pharma Co.Ltd,No.368 Zhen'an Middle Road,Dongguan 523871,Guangdong Province,China

出　　处：《Medical Review》2023年第5期425-443,共19页医学评论（英文）

摘　　要：Boron neutron capture therapy(BNCT)is a potential radiation therapy modality for cancer,and tumortargeted stable boron-10(10B)delivery agents are an important component of BNCT.Currently,two low-molecular-weight boron-containing compounds,sodium mercaptoundecahydrocloso-dodecaborate(BSH)and boronophenylalanine(BPA),are mainly used in BNCT.Although both have suboptimal tumor selectivity,they have shown some therapeutic benefit in patients with high-grade glioma and several other tumors.To improve the efficacy of BNCT,great efforts have been devoted for the development of new boron delivery agents with better uptake and favorable pharmacokinetic profiles.This article reviews the application and research progress of boron nanomaterials as boron carriers in boron neutron capture therapy and hopes to stimulate people’s interest in nanomaterial-based delivery agents by summarizing various kinds of boron nanomaterial patents disclosed in the past decade.

关 键 词：boron agent boron neutron capture therapy DENDRIMER drug delivery NANOMATERIAL 

分 类 号：TB383[一般工业技术—材料科学与工程]