Circulating Lipoproteins Mediate the Association Between Cardiovascular Risk Factors and Cognitive Decline:A Community‑Based Cohort Study  

作　　者：Jialin Li Qingxia Huang Yingzhe Wang Mei Cui Kelin Xu Chen Suo Zhenqiu Liu Yanpeng An Li Jin Huiru Tang Xingdong Chen Yanfeng Jiang 

机构地区：[1]State Key Laboratory of Genetic Engineering,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,and National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,2005 Songhu Rd,Shanghai 200438,China [2]Fudan University Taizhou Institute of Health Sciences,Taizhou 225326,China [3]State Key Laboratory of Genetic Engineering,School of Life Sciences,Metabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular Phenomics,Human Phenome Institute,Zhongshan Hospital,Fudan University,2005 Songhu Rd,Shanghai 200438,China [4]Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China [5]Ministry of Education Key Laboratory of Public Health Safety,Department of Biostatistics,School of Public Health,Fudan University,Shanghai 200032,China [6]Ministry of Education Key Laboratory of Public Health Safety,Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China [7]Shanghai Institute of Infectious Disease and Biosecurity,Shanghai 200032,China [8]Yiwu Research Institute of Fudan University,Yiwu 322000,Zhejiang,China [9]International Human Phenome Institute(Shanghai),Shanghai 201203,China [10]Greater Bay Area Institute of Precision Medicine(Guangzhou),Fudan University,Guangzhou 511462,China

出　　处：《Phenomics》2024年第1期51-55,共5页表型组学（英文）

基　　金：the National Key Research and Development program of China(2022YFC3400700,2022YFA0806400,2021YFC2500100,2020YFE0201600);the Science and Technology Innovation 2030 Major Projects(2022ZD0211600);the Shanghai Rising-Star Program(22QA1404000);Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);the Natural Science Foundation of Shanghai,China(22ZR1405300);the National Natural Science Foundation of China(31821002);the Key Research and Development Plans of Jiangsu Province,China(BE2021696);the Greater Bay Area Institute of Precision Medicine(Guangzhou).

摘　　要：Cardiovascular health metrics are now widely recognized as modifable risk factors for cognitive decline and dementia.Metabolic perturbations might play roles in the linkage of cardiovascular diseases and dementia.Circulating metabolites profling by metabolomics may improve understanding of the potential mechanism by which cardiovascular risk factors contribute to cognitive decline.In a prospective community-based cohort in China(n=725),312 serum metabolic phenotypes were quantifed,and cardiovascular health score was calculated including smoking,exercise,sleep,diet,body mass index,blood pressure,and blood glucose.Cognitive function assessments were conducted in baseline and follow-up visits to identify longitudinal cognitive decline.A better cardiovascular health was signifcantly associated with lower risk of concentration decline and orientation decline(hazard ratio(HR):0.84–0.90;p<0.05).Apolipoprotein-A1,high-density lipoprotein(HDL)cholesterol,cholesterol ester,and phospholipid concentrations were signifcantly associated with a lower risk of longitudinal memory and orientation decline(p<0.05 and adjusted-p<0.20).Mediation analysis suggested that the negative association between health status and the risk of orientation decline was partly mediated by cholesterol ester and total lipids in HDL-2 and-3(proportion of mediation:7.68–8.21%,both p<0.05).Cardiovascular risk factors were associated with greater risks of cognitive decline,which were found to be mediated by circulating lipoproteins,particularly the medium-size HDL components.These fndings underscore the potential of utilizing lipoproteins as targets for early stage dementia screening and intervention.

关 键 词：Cardiovascular risk factors LIPOPROTEINS LIPIDS COGNITION Cognitive decline 

分 类 号：R54[医药卫生—心血管疾病]