The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses  

作　　者：Cong Sun Jia-Wen Yang Chu Xie Xin-Yan Fang Guo-Long Bu Ge-Xin Zhao Dan-Ling Dai Zheng Liu Mu-Sheng Zeng 

机构地区：[1]State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangdong,China [2]Cryo-electron Microscopy Center,Southern University of Science and Technology,Guangdong,China [3]Department of Biology,Southern University of Science and Technology,Guangdong,China

出　　处：《hLife》2024年第3期141-146,共6页健康科学（英文）

基　　金：supported by grants from the NationalKey Research and Development Program of China(2022YFC3400900);Chinese Postdoctoral Science Foundation(GZB20230886,2023M743998);Natural Science Foundationof China(82030046 to M.S.Z,82070329 and 32241028 toZ.L.);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2019BT02Y198);Guangdong Science and Technology Department(2020B1212030004).

摘　　要：Human herpesviruses(HHV),including the alpha,beta,andgamma subfamilies,are enveloped viruses with broad prevalence,establishing life-time latent infections and inducing a variety of diseases[1].Among them,herpes simplex virus(HSV),consists of two HSV-1 and HSV-2 variants,ubiquitouslyaffecting global populations[2].As an enveloped virus,HSV features a repertoire of glycoproteins such as glycoproteins D(gD),glycoproteins H(gH),glycoproteins L(gL),and glycoproteins B(gB),to orchestrate host cell recognition and infection[3,4].

关 键 词：diseases neutral ENVELOPE 

分 类 号：R373[医药卫生—病原生物学]