Polymyxin sensitivity/resistance cosmopolitan status,epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae:A meta-analysis  

作　　者：Bright E.Igere Hope Onohuean Declan C.Iwu Etinosa O.Igbinosa 

机构地区：[1]Department of Biological Sciences,Microbiology Unit,Dennis Osadebay University,Asaba 320242,Nigeria [2]Biotechnology and Emerging Environmental Infections Pathogens Research Group(BEEIPREG),Department of Biological Sciences,Microbiology Unit,Dennis Osadebay University,Asaba 320242,Nigeria [3]Biopharmaceutics unit,Department of Pharmacology and Toxicology,School of Pharmacy,Kampala International University Ishaka-Bushenyi Campus,Ishaka-Bushenyi 10101,Uganda [4]Department of Microbiology,University of Pretoria,Pretoria 0002,South Africa [5]Department of Microbiology,Faculty of Life Sciences,University of Benin,Benin 300213,Nigeria

出　　处：《Infectious Medicine》2023年第4期283-293,共11页感染医学（英文）

基　　金：funds provided by African German Network of Excellence in Science 2022 (AGNES-2022).

摘　　要：Resistance/sensitivity to polymyxin-B(PB)antibiotic has been employed as one among other epidemiologically relevant biotyping-scheme for Vibrio cholerae into Classical/El Tor biotypes.However,recent studies have re-vealed some pitfalls bordering on PB-sensitivity/resistance(PBR/S)necessitating study.Current study assesses the PBR/S cosmopolitan prevalence,epidemiology/distribution among O1/O139 and nonO1/nonO139 V.cholerae strains.Relevant databases(Web of Science,Scopus and PubMed)were searched to retrieve data from environ-mental and clinical samples employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA).Random-effect-model(REM)and common-effect-model(CEM)of meta-analysis was performed to de-termine prevalence of PBR/S V.cholerae strains,describe the cosmopolitan epidemiological potentials and biotype relevance.Heterogeneity was determined by meta-regression and subgroup analyses.The pooled analyzed iso-lates from articles(7290),with sensitive and resistance are 2219(30.44%)and 5028(69.56%).Among these PB-sensitive strains,more than 1944(26.67%)were O1 strains,132(1.81%)were nonO1 strains while mis-reported Classical biotype were 2080(28.53)respectively indicating potential spread of variant/dual biotype.A significant PB-resistance was observed in the models(CEM=0.66,95%CI[0.65;0.68],p-value=0.001;REM=0.83[0.74;0.90],p=0.001)as both models had a high level of heterogeneity(I^(2)=98.0%;^(2)_(df=33)=1755.09,Qp=2.4932).Egger test(z=5.4017,p<0.0001)reveal publication bias by funnel plot asymmetry.The subgroup analysis for continents(Asia,Africa)and sources(acute diarrhea)revealed(98%CI(0.73;0.93);55%CI(0.20;0.86)),and 92%CI(0.67;0.98).The Epidemiological prevalence for El tor/variant/dual biotype showed 88%CI(0.78;0.94)with O1 strains at 88%CI(0.78;0.94).Such global prevalence,distribution/spread of phenotypes/genotypes ne-cessitates updating the decades-long biotype classification scheme.An antibiotic stewardship in the post antibiotic era is suggestive/recommended.Also,there is n

关 键 词：Biotyping scheme Environmental nonO1/nonO139 V.cholerae Clinical O1/O139 V.cholerae PB-sensitive/PB-resistant strains Global epidemiological relevance Polymyxin B 

分 类 号：R51[医药卫生—内科学] R18[医药卫生—临床医学]