Swarming magnetic photonic-crystal microrobots withon-the-fly visual pH detection and self-regulated drug delivery  

作　　者：Zheng Yu Luolin Li Fangzhi Mou Shimin Yu Di Zhang Manyi Yang Qing Zhao Huiru Ma Wei Luo Tianlong Li Jianguo Guan 

机构地区：[1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and Engineering,Wuhan University of Technology,Wuhan,the People's Republic of China [2]State Key Laboratory of Robotics and System,Harbin Institute of Technology,Harbin,the People's Republic of China [3]Wuhan Institute of Photochemistry and Technology,Wuhan,the People's Republic of China

出　　处：《InfoMat》2023年第10期64-79,共16页信息材料（英文）

基　　金：National Key Research and Development Program,Grant/Award Numbers:2021YFA1201400,2022YF B4701700;National Natural Science Foundation of China,Grant/Award Numbers:21875175,52073222,52175009;Interdisciplinary Research Foundation of HIT,Grant/Award Number:1R20211219;Natural Science Foundation of Chonging,Grant/Award Number:CSTB2022NSCQ-MSX0507;Natural Science Foundation of Heilongian Province,Grant/Award Number.YQ2022E022;Central University Basic Research Fund of China,Grant/Award Number:2022IVA201。

摘　　要：Swarming magnetic micro/nanorobots hold great promise for biomedical applications,but at present suffer from inferior capabilities to perceive and respond to chemical signals in local microenvironments.Here we demonstrate swarming magnetic photonic crystal microrobots(PC-bots)capable of sponta-neously performing on-the-fly visual pH detection and self regulated drug delivery by perceiving local pH changes.The magnetic PC-bots consist of pH-responsive hydrogel microspheres with encapsulated one-dimensional periodic assemblies of Fe3O4 nanoparticles.By programming extemnal rotating magnetic fields,they can self-organize into large swarms with much-enhanced collective velocity to actively find targets while shining bright“blinking”structural colors.When approaching the target with abnormal pH conditions(e.g.an ulcerated superficial tumor lesion),the PC-bots can visualize local pH changes on the fly via pH-responsive structural colors,and realize self-regulated release of the loaded drugs by recognizing local pH.This work facilita tes the develop-ment of intelligent micro/nanorobots for active“motile-targeting”tumor diag-nosis and treatment.

关 键 词：collective behaviors drug delivery micro/nanorobots on-the-fly sensing responsivephotonic crystals 

分 类 号：TP242[自动化与计算机技术—检测技术与自动化装置]