Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals  

作　　者：Chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus Chee Fu Yung Wee Chee Yap Beng Lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah Eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang 

机构地区：[1]Programme in Emerging Infectious Diseases,Duke-NUS Medical School,Singapore [2]National Center of Infectious Diseases,Singapore [3]Tan Tock Seng Hospital,Singapore [4]Lee Kong Chian School of Medicine,Nanyang Technology University,Singapore [5]Centre Scientifique de Monaco,Monaco [6]Direction de I’Action Sanitaire de Monaco,Monaco [7]Infectious Disease Service,Department of Pediatrics,KK Women’s and Children’s Hospital,Singapore [8]Duke-NUS Medical School,Singapore [9]African Health Research Institute,Durban,South Africa [10]Singapore Immunology Network,Agency for Science,Technology and Research,Singapore [11]Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore [12]Department of Microbiology and Immunology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore [13]Infectious Diseases Translational Research [14]Programme,National University of Singapore,Singapore 14School of Biological Sciences,Nanyang Technological University,Singapore [15]Singhealth Duke-NUS Global Health Institute,Singapore

出　　处：《hLife》2023年第1期26-34,共9页健康科学（英文）

基　　金：supported in part by grants from the National Medical Research Council(COVID19RF-001,COVID19RF-003,COVID19RF-0008,COVID19RF-0014,COVID19RF-0018,COVID19RF3-0060,MOH-000535/MOH-OFYIRG19nov-0002 and MOH-000505-02);SingHealth Duke-NUS Academic Medicine COVID-19 Rapid Response Research Grant(AM/COV001/2020);Collaborative Research Fund(C2103-20GF);Wellcome COVID-19 Grant on Understanding the Biological Significance SARS-CoV-2 Variants(226120/Z/22/Z);National Institute of Health NIAID(R01AI163118 and 5U01AI151797);National Public Health COVID Program of the Government of Monaco.

摘　　要：Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study.The key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding variants.This raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus.Here,we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta,Delta,Omicron BA.1,Omicron BA.2 and Omicron BA.5.The results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1,ancestral SARS-CoV-2 and SARS-CoV-2 Omicron subvariants.The data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.

关 键 词：SARS-CoV-2 SARS-CoV-1 SEROTYPE Omicron primary infection convalescent sera 

分 类 号：R446.11[医药卫生—诊断学]