Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets  

作　　者：Lei Qiao Xina Dou Xiaofan Song Jiajing Chang Xiaonan Zeng Lixu Zhu Hongbo Yi Chunlan Xu 

机构地区：[1]School of Life Sciences,Northwestern Polytechnical University,Xi'an,Shaanxi 710072,China [2]State Key Laboratory of Livestock and Poultry Breeding,Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China,Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition,Institute of Animal Science of Guangdong Academy of Agricultural Sciences,Guangzhou,Guangdong 510640,China

出　　处：《Animal Nutrition》2023年第4期99-113,共15页动物营养（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.32072746);the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University(No.CX2021029,No.CX2022062).

摘　　要：Selenium nanoparticles(SeNPs)are proposed as a safer and more effective selenium delivery system than sodium selenite(Na_(2)SeO_(3)).Here,we investigated the effects of replacing dietary Na_(2)SeO_(3)with SeNPs synthesized by Lactobacillus casei ATCC 393 on the growth performance and gut health of earlyweaned piglets.Seventy-two piglets(Duroc×Landrace×Large Yorkshire)weaned at 21 d of age were divided into the control group(basal diet containing 0.3 mg Se/kg from Na_(2)SeO_(3))and SeNPs group(basal diet containing 0.3 mg Se/kg from SeNPs)during a 14-d feeding period.The results revealed that SeNPs supplementation increased the average daily gain(P=0.022)and average daily feed intake(P=0.033),reduced(P=0.056)the diarrhea incidence,and improved(P=0.013)the feed conversion ratio compared with Na_(2)SeO_(3).Additionally,SeNPs increased jejunal microvilli height(P=0.006)and alleviated the intestinal barrier dysfunction by upregulating(P<0.05)the expression levels of mucin 2 and tight junction proteins,increasing(P<0.05)Se availability,and maintaining mitochondrial structure and function,thereby improving antioxidant capacity and immunity.Furthermore,metabolomics showed that SeNPs can regulate lipid metabolism and participate in the synthesis,secretion and action of parathyroid hormone,proximal tubule bicarbonate reclamation and tricarboxylic acid cycle.Moreover,SeNPs increased(P<0.05)the abundance of Holdemanella and the levels of acetate and propionate.Correlation analysis suggested that Holdemanella was closely associated with the regulatory effects of SeNPs on early-weaned piglets through participating in lipid metabolism.Overall,replacing dietary Na_(2)SeO_(3)with biogenic SeNPs could be a potential nutritional intervention strategy to prevent earlyweaning syndrome in piglets.

关 键 词：Selenium nanoparticle Early-weaned piglet Gut homeostasis Gut microbiota 

分 类 号：S828.5[农业科学—畜牧学]