An in vitro Anti-urolithiasis Activity of a Herbal Formulation:Spinacia oleracea L.and Coriandrum sativum L.  

作　　者：Sumathy Raj Monica Shree Gnana Soundara Rajan Suganthi Ramasamy Rimal Isaac Rajamony Suthies Goldy Ramathilaga Ariyamuthu Monisha Sudhagar Sakthivel Gandhi Prakash Shoba Manikandan Gurusamy 

机构地区：[1]School of Biotechnology,Dr.G.R.Damodaran College of Science,Coimbatore,Tamil Nadu,India [2]Department of Biotechnology,Dr.N.G.P Arts and Science College,Coimbatore,Tamil Nadu,India [3]Department of Nanotechnology,Noorul Islam Centre for Higher Education,Kumaracoil,Thuckalay,Kanyakumari District,Tamil Nadu,India [4]PG and Research Department of Biochemistry,Kongunadu Arts and Science College,Coimbatore,Tamil Nadu,India [5]Department of Biological and Chemical Engineering,Mekelle University,Mekelle,Ethipoia [6]Department of Zoology,Holy Cross College(Autonomous),Nagercoil,Tamilnadu,India [7]Department of Pharmaceutical Sciences,Tshwane University of Technology,Arcadia Campus,Pretoria,South Africa

出　　处：《Clinical Complementary Medicine and Pharmacology》2024年第1期76-84,共9页临床补充医学和药理学（英文）

摘　　要：Background:Hard mineral and acid salt deposits that clump together in concentrated urine are known as kidney stones.A complicated chain of physicochemical events,including hyper saturation,nucleation,growth,aggrega-tion,and retention in the urinary tract,leads to urolithiasis,the third most prevalent urinary tract issue.Numerous traditional medications and therapies are less successful in treating urolithiasis and frequently cause recurrences.Objective:The present study is focused on evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from Spinacia oleracea L.and Coriandrum sativum L.seeds.Methods:To evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from S.oleracea and C.sativum seeds against oxalate crystals by employing an in vitro inhibition,aggregation,and nucleation assay,employing a spectrophotometer followed by microscopic observation,and further monitored by egg semiperme-able membrane model,using cystone as a standard drug.Results:In the present work,the alkaloids,glycosides,flavonoids,glycosides,phenols,saponins,steroids,tannins,terpenoids,and triterpenoids were found in the extracts of S.oleracea and C.sativum.The in vitro assays in the present study clearly indicated that all the mixture extracts readily prevented crystal nucleation,growth and ag-gregation.The aqueous extract of the mixture inhibited significant inhibitory potential against the crystallization process.Conclusion:It can be said that the phyto-constituents enriched homemade preparation possibly will be used as a medication for the management of kidney stones by dissolving the oxalate stone in the kidney.

关 键 词：UROLITHIASIS POLYHERBAL Egg membrane Spinacia oleracea Coriandrum sativum 

分 类 号：R28[医药卫生—中药学]