纳米方钠石的制备及其载药抗菌性能  

Preparation of Nano-sodalite and Its Drug-loading and Antibacterial Properties

作　　者：于亚鑫 刘志刚 王春梅 杨立荣 YU Ya-xin;LIU Zhi-gang;WANG Chun-mei;YANG Li-rong(College of Materials Science and Engineering,North China University of Science and Technology,Tangshan Hebei 063210,China;Hebei Provincial Key Laboratory of Inorganic non-metallic materials,Tangshan Hebei 063210,China;Hebei Technology Innovation Center for Comprehensive Utilization of Industrial Solid Waste,Tangshan Hebei 063210,China)

机构地区：[1]华北理工大学材料科学与工程学院,河北唐山063210 [2]河北省无机非金属材料重点实验室,河北唐山063210 [3]河北省工业固废综合利用技术创新中心,河北唐山063210

出　　处：《华北理工大学学报（自然科学版）》2024年第1期89-96,共8页Journal of North China University of Science and Technology：Natural Science Edition

基　　金：河北省自然科学基金项目(E2020209193)。

摘　　要：以正硅酸乙酯为硅源、氢氧化铝为铝源,在Na/Al摩尔比为4、温度和时间分别为90℃和12 h时的条件下,通过溶剂热法制备了纳米方钠石,并以纳米方钠石为载体负载姜黄素,研究了载药温度、载药pH、药物浓度等因素对纳米方钠石载药性能的影响,并探讨了其抗菌性,通过XRD、SEM和BET等测试分析了样品的结构和形貌。结果表明,纳米方钠石的晶粒粒径大约为13.4 nm,当载药温度为50℃、载药液相pH为4.2时,纳米方钠石对姜黄素的包封量明显优于其它样品,显示出优异的抗菌性。最高药物包封量可达857 mg/g,包封率为86%,抑菌率高达91.4%。Nano-sodalite was synthesized by solvothermal method using ethyl orthosilicate as the silicon source and aluminum hydroxide as the aluminum source with the Na/Al molar ratio of 4,solvothermal temperature of 90 ℃ and solvothermal time of 12 h,respectively.The effects of drug-loading temperature,drug-loading pH,drug concentration on the drug-loading properties of nano-sodalite were researched using the nano-sodalite as curcumin carrier.And its antibacterial property was discussed.The structure and morphology of the samples were analyzed by XRD,SEM and BET tests.The results show that the grain size of nano-sodaliteis about 13.4 nm.The curcumin encapsulation capacity of nano-sodalite synthesized at drug loading temperature of 50 ℃ and the liquid phase pH of 4.2 is significantly better than that of other samples and exhibitsan excellent antibacterial property.Its maximum drug encapsulation capacity,encapsulation efficiency and antibacterial efficiency is 857 mg/g,86% and 91.4%,respectively.

关 键 词：纳米方钠石 溶剂热 姜黄素 载药性 

分 类 号：TB383[一般工业技术—材料科学与工程]