水凝胶中的抗菌技术  

Antibacterial technologies in hydrogels

作　　者：陈雨默 杨瑞昊 吴勇杰 张更鑫 孙康[1] 陶可[1] CHEN Yumo;YANG Ruihao;WU Yongjie;ZHANG Gengxin;SUN Kang;TAO Ke(The State Key Lab of Metal Matrix Composites,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海交通大学材料科学与工程学院,金属基复合材料国家重点实验室,上海200240

出　　处：《功能材料》2024年第3期3001-3008,3022,共9页Journal of Functional Materials

基　　金：国家自然科学基金(31671027)。

摘　　要：细菌感染及其耐药性是当今世界面临的巨大健康难题之一,每年给全世界造成了巨大的人员伤亡和经济损失。水凝胶是一种三维聚合物网络结构胶体,其亲水性好,具备独特的三维网络、良好的生物相容和细胞粘附性,因而水凝胶是一种适用于抗菌领域的新型生物材料,也有望于成为解决抗生素耐药性的潜力抗菌材料。根据相应的抗菌方式,水凝胶中的抗菌技术可以大致归纳为以下几类:(i)负载抗菌物质水凝胶;(ii)具有固有抗菌活性水凝胶;(iii)利用光响应疗法的抗菌水凝胶。文章简略介绍各种水凝胶抗菌技术的基本原理,方法和应用,并对未来存在的困难和挑战进行初步探讨。Bacterial infections and their drug resistance are one of the enormous health challenges in the world today,causing huge casualties and economic losses worldwide every year.Hydrogel is a three-dimensional polymer network structure colloid with good hydrophilicity,unique three-dimensional network,good biocompatibility and cell adhesion.Therefore,hydrogel is a new type of biomaterial suitable for the antibacterial application and is expected to become a potential antibacterial material to solve antibiotic resistance.According to the corresponding antibacterial methods,the antibacterial technologies in hydrogels can be roughly classified into the following categories:(i)hydrogels loaded with antibacterial substances;(ii)hydrogels with inherent antibacterial activity;(iii)antibacterial hydrogels using photoresponsive therapy.This article will briefly introduce the basic principles,methods and applications of various hydrogel antibacterial technologies,and preliminarily discuss the difficulties and challenges in the future.

关 键 词：水凝胶 抗菌材料 细菌感染 光响应疗法 

分 类 号：O644.1[理学—物理化学] O636.9[理学—化学] R318.08[医药卫生—生物医学工程]