Protection of Viola odorata L.against Neurodegenerative Diseases:Potential of the Extract and Major Phytoconstituents  

作　　者：Sunny Dhiman Shivali Singla Inder Kumar Priyankul Palia Pankaj Kumar Sachin Goyal 

机构地区：[1]Department of Pharmacology,School of Pharmacy,Abhilashi University,Chail-Chowk 175028,Himachal Pradesh,India [2]Department of Pharmaceutics,School of Pharmacy,Abhilashi University,Chail-Chowk 175028,Himachal Pradesh,India [3]Department of Pharmaceutical Chemistry,School of Pharmacy,Abhilashi University,Chail-Chowk 175028,Himachal Pradesh,India

出　　处：《Clinical Complementary Medicine and Pharmacology》2023年第3期78-89,共12页临床补充医学和药理学（英文）

摘　　要：Background:Neurodegenerative diseases cause cognitive impairment owing to neuronal death and deterioration.Only a few brain-protecting chemical investigations yielded neuroprotective medications.Viola odoata L.is a traditional medicinal herb that has lately been shown to have strong pharmacological effectiveness against major neurological illnesses with fewer adverse effects.Objective:The objective of the current review is to provide a thorough overview of the key biologically active components and extract of Viola odorata L.in their capacity to safeguard nerve cells.Methods:Science Direct,PubMed,Springer Nature,and Google Scholar were scoured for relevant articles using the terms“Viola odorata L.”,and in the heading and abstract or main text,“neuroprotective activity”,“neurode-generative disease”,“pharmacological potential”,and“therapeutic activity”along with“extract”or“phytocon-stituents”.Neuroprotective activity of Viola odorata L.extract or phytoconstituents were used to classify and investigate the articles that passed the screening process.Results:A total of one hundred twenty one papers were reviewed based on the collected data.The following topics have been elaborated upon in the text:pathological factors of neurodegenerative diseases;role of medic-inal plants in neurodegenerative diseases;Viola odorata L.taxonomy,pharmacological activities,toxicity and adverse effect;neuroprotective activity of extract and various active components of Viola odorata L.The primary phytocomponents of Viola odorata L.were discovered to be anthocyanins,flavonoids,melatonin,salicylic acid,cumarins and various alkaloids,which are primarily responsible for its neuroprotective action.These natural plant compounds can boost antioxidant levels,reduce harmful oxidants,alleviate nerve pain,decrease the pro-duction of pro-inflammatory cytokines such as IL-6,IL-1β,and TNF-α𝛼,lower the total amount of nitrite produced,and trigger various neuroprotective mechanisms in the nervous system.It has been also c

关 键 词：Viola odorat L. Neuroprotective effect Antioxidant activity Neurological disease 

分 类 号：R285[医药卫生—中药学]