脑源性神经营养因子和神经营养因子-5在女性生殖内分泌领域的研究进展  

Research progress of brain derived neurotrophic factor and neurotrophin 5 in female reproductive endocrine system

作　　者：娄艳茹 刘晨虹 严杰[1] 杨蕊[1] LOU Yan-ru;LIU Chen-hong;YAN Jie;YANG Rui(Center for Reproductive Medicine,Department of Obstetrics&Gynecology,Peking University Third Hospital,State Key Laboratory of Female Fertility Promotion,National Clinical Research Center for Obstetrics&Gynecology,Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education,Beijing Key Laboratory of Reproductive Endocrinology&Assisted Reproductive Technology,Beijing 100191)

机构地区：[1]北京大学第三医院妇产科生殖医学中心,女性生育力促进全国重点实验室,国家妇产疾病临床医学研究中心,辅助生殖教育部重点实验室,北京市生殖内分泌与辅助生殖技术重点实验室,北京100191

出　　处：《生殖医学杂志》2024年第4期540-545,共6页Journal of Reproductive Medicine

基　　金：国家自然科学基金项目(82171632,T2293764);国家重点研发计划课题(2021YFC2700605,2022YFC2703000)。

摘　　要：脑源性神经营养因子(BDNF)和神经营养因子-5(NT-5)属于神经营养因子家族,是一类由神经支配的靶组织分泌的分泌型多肽,两者通过作用于相同的受体发挥作用。BDNF和NT-5在卵巢表达广泛,发挥着促进卵泡组装和发育、卵母细胞成熟、排卵、调节颗粒细胞和膜细胞类固醇激素分泌等多种生理作用。不孕症是由多种病因导致的一种生育障碍状态,不孕症患者卵巢局部的BDNF和NT-5存在异常分泌情况。因此,了解BDNF和NT-5在女性生殖内分泌领域的研究进展,可能为不孕症治疗提供新方向,为辅助生殖结局的预测提供新指标。Brain derived neurotrophic factor(BDNF)and neurotrophin-5(NT-5),which act on the same receptors-TrkB and p75NTR,are members of neurotrophin family and a kind of secretory polypeptides which are secreted by the target tissue innervated by nerves.BDNF and NT-5 are widely expressed in the ovary and play important roles in multiple reproductive physiological activities,such as follicular assembly and development,oocyte maturation,ovulation and steroidogenesis in granulosa and theca cells.Infertility is a reproductive disorder caused by multiple etiology.Among infertile patients,there is an abnormal secretion of BDNF and NT-5 in the ovary.Therefore,understanding the research progress of BDNF and NT-5 in female reproductive endocrine system may provide new directions for the treatment of infertility and new indicators for predicting pregnancy outcomes of assisted reproduction.

关 键 词：脑源性神经营养因子 神经营养因子-5 酪氨酸激酶受体B 不孕症 

分 类 号：R711.6[医药卫生—妇产科学]